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Study aim
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Comparison the effect of propofol and isoflurane on hemodynamics parameters and stress response hormones during laparoscopic cholecystectomy.
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Design
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Patients are randomly divided into two intervention groups and the study is design as a randomised, parallel group trial with single blinded outcome assessment.
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Settings and conduct
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Seventy patients candidate of laparoscopic cholecystectomy in age group 20 to 60 years are randomly divided into intervention (1) and (2) group. The combination of midazolam (0.05 mg/kg), fentanyl (2 µg/kg), sodium thiopental (4 mg/kg), atracurium (0.5 mg/kg) is used to induce anesthesia.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria are patients with symptomatic gallstone disease or acute cholecystitis, patients without inside or outside biliary tract dilatation and American Society of Anesthesiologists (ASA) classification I , II; The exclusion criteria are obesity patients with class II or III (BMI>35), patients with chronic liver disease, diabetes, renal failure, endocrine problems, rheumatoid arthritis, cardiovascular disease or malignancy, patients receiving drugs with known effects on sympathetic response or hormone secretion, patients receiving benzodiazepines and pregnant or lactating mothers.
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Intervention groups
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In the Intervention group (1), intravenous injection of propofol 50-150 µg/kg/min is performed and in the intervention group (2), isoflurane with mac: 1.28% atm/mmhg is vaporized and patients inhale.
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Main outcome variables
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Mean arterial pressure and heart rate in time of starting the operation, every 5 minutes during the time between start of surgery till the completion of the surgical operation and 20 minutes after attending to recovery room are measured. Epinephrine and blood glucose level are measured via blood test before starting the operation (after anesthesia induction) and after finish running suturing (before reverse).