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The effect of 12 weeks circuit resistance training with three different intensities equal volume on serum level of some muscle growth factors in obese men

Protocol summary

Study aim
Which of the three intensities would have a better impact on obesity, myokines, and adipomycins? What will be the relationship between myokines and the adipomycokines of decorin, myostatin, folistatin and TGF-β1 in obese individuals? The aim of the present study was to investigate the effect of twelve weeks of circular resistance training of the same volume in three low (40%), moderate (60) and high (80%) intensities on Decourine, Folistatin, Myostatin and TGF-β1 in obese men.
Design
The circular resistance training protocol consisted of 8 upper and lower trunk movements (squat, arm forward, chest press, knee bending, knee bending, shoulder bar, leg press, arm wiring behind) circular and It will be investigated at different intensities
Settings and conduct
The field of study will be the study of obesity and its complications. The type of research will be experimental, in which practical intervention is performed without a manufacturing process.
Participants/Inclusion and exclusion criteria
Conditions of entry into the study of drug and alcohol addiction research, lack of regular exercise for at least 6 months, no history of kidney, liver, cardiovascular disease, diabetes, and conditions (BMI≥30, Waist-to-height ratio ( WHtR)> 0.5) and no harm or physical injury to the subjects and will be included in the study after a cardiologist examination and general health approval.
Intervention groups
control group 40% training group 60% practice group 80% training group
Main outcome variables
Serum levels follistatin and myostatin, decorin and TGF-B1

General information

Reason for update
Acronym
IRCT registration information
IRCT registration number: IRCT20190627044037N1
Registration date: 2020-09-22, 1399/07/01
Registration timing: retrospective

Last update: 2020-09-22, 1399/07/01
Update count: 0
Registration date
2020-09-22, 1399/07/01
Registrant information
Name
Saber Niazi
Name of organization / entity
Kharazmi University
Country
Iran (Islamic Republic of)
Phone
+98 51 5523 1954
Email address
std_saber.niazi@khu.ac.ir
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2019-10-23, 1398/08/01
Expected recruitment end date
2020-08-22, 1399/06/01
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
The effect of 12 weeks circuit resistance training with three different intensities equal volume on serum level of some muscle growth factors in obese men
Public title
Comparison of three intensities of circular resistance training of equal volume on factors related to muscle growth in obese men
Purpose
Supportive
Inclusion/Exclusion criteria
Inclusion criteria:
Volunteer obese men No drug and alcohol addiction Having no history of regular exercise for at least 6 months No history of kidney, liver, cardiovascular disease, diabetes BMI≥30، Waist-to-height ratio (WHtR)>0.5) age between 23 to 32
Exclusion criteria:
Drug and alcohol addiction Having a history of regular exercise Having a history of kidney, liver, cardiovascular disease, diabetes BMI<30، Waist-to-height ratio (WHtR)<0.5) 32<age<23
Age
From 23 years old to 32 years old
Gender
Male
Phase
3
Groups that have been masked
No information
Sample size
Target sample size: 44
Randomization (investigator's opinion)
Not randomized
Randomization description
Blinding (investigator's opinion)
Not blinded
Blinding description
Placebo
Not used
Assignment
Parallel
Other design features
Comparison and evaluation of optimal intensity of circular resistance training to reduce adipose tissue and help improve muscle tissue in obese men

Secondary Ids

empty

Ethics committees

1

Ethics committee
Name of ethics committee
Sport Sciences Research Institute
Street address
bagh feyz street, janat allye,
City
tehran
Province
Tehran
Postal code
9671945754
Approval date
2020-08-19, 1399/05/29
Ethics committee reference number
IR.SSRC.REC.1399.064

Health conditions studied

1

Description of health condition studied
Obesity
ICD-10 code
E66
ICD-10 code description
Overweight and obesity

Primary outcomes

1

Description
decorin
Timepoint
pre and post exercise
Method of measurement
Elisa reader

2

Description
folistatin
Timepoint
pre and post exercise
Method of measurement
Elisa

3

Description
myostatin
Timepoint
pre and post exercise
Method of measurement
Elisa

4

Description
TGF-b1
Timepoint
pre and post exercise
Method of measurement
Elisa

Secondary outcomes

empty

Intervention groups

1

Description
intensity 40%(40%1RM). Calculate and estimate the intensity of resistance training activity of the samples as much as 40% of the maximum strength of each sample. Circular resistance training means doing exercises with sports machines in a stationary manner and in sequence. These sports movements number 8 moves. It will be three times a week for 12 weeks.
Category
Rehabilitation

2

Description
Intervention group: 60% intensity(60%1RM). Calculate and estimate the intensity of resistance training activity of the samples as much as 60% of the maximum strength of each sample. Circular resistance training means doing exercises with sports machines in a stationary manner and in sequence. These sports movements number 8 moves. It will be three times a week for 12 weeks.
Category
Rehabilitation

3

Description
Intervention group: 80% intensity(80% 1RM). Calculate and estimate the intensity of resistance training activity of the samples as much as 80% of the maximum strength of each sample. Circular resistance training means doing exercises with sports machines in a stationary manner and in sequence. These sports movements number 8 moves. It will be three times a week for 12 weeks.
Category
Rehabilitation

4

Description
Control group: no exercise
Category
Rehabilitation

Recruitment centers

1

Recruitment center
Name of recruitment center
Kharazmy university of tehran
Full name of responsible person
Saber Niazi
Street address
Bagh feyz, Janat street
City
Tehran
Province
Tehran
Postal code
9671975545
Phone
+98 21 2243 2061
Fax
+98 21 2243 2061
Email
Saber_niazi@yahoo.com
Web page address

Sponsors / Funding sources

1

Sponsor
Name of organization / entity
The University of Kharazmy
Full name of responsible person
Hamid Rajabi
Street address
Baghe feyz, Janat street
City
Tehran
Province
Tehran
Postal code
9671956745
Phone
+98 21 2243 2961
Fax
+98 21 2243 2061
Email
Saber_Niazi@yahoo.com
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
No
Title of funding source
student research grant
Proportion provided by this source
30
Public or private sector
Public
Domestic or foreign origin
Domestic
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
Academic

Person responsible for general inquiries

Contact
Name of organization / entity
The University of Tehran Kharazmy
Full name of responsible person
Hamid Rajabi
Position
professor
Latest degree
Ph.D.
Other areas of specialty/work
Physiology
Street address
mirdamad,faculty of physical education and sport science
City
Tehran
Province
Tehran
Postal code
9671956475
Phone
+98 21 2243 2061
Email
Saber_niazi@yahoo.com
Web page address
https://khu.ac.ir/cv/399/%D8%AD%D9%85%DB%8C%D8%AF%20%D8%B1%D8%AC%D8%A8%DB%8C

Person responsible for scientific inquiries

Contact
Name of organization / entity
Kharazmy University of Tehran
Full name of responsible person
Saber Niazi
Position
PhD student
Latest degree
Ph.D.
Other areas of specialty/work
Physiology
Street address
Uint7, nom4. 8east. Kafi masooleh ave, 22 Bahman blvd. bagh feyz, tehran
City
Tehran
Province
Tehran
Postal code
9671974574
Phone
+98 21 2243 2061
Email
Saber_Niazi@yahoo.com

Person responsible for updating data

Contact
Name of organization / entity
Kharazmy University of Tehran
Full name of responsible person
Saber Niazi
Position
PhD student
Latest degree
Ph.D.
Other areas of specialty/work
Physiology
Street address
Baghe feyz, Janat street
City
Tehran
Province
Tehran
Postal code
9671947547
Phone
+98 21 2243 2061
Email
saber_niazi@yahoo.com

Sharing plan

Deidentified Individual Participant Data Set (IPD)
Yes - There is a plan to make this available
Study Protocol
Yes - There is a plan to make this available
Statistical Analysis Plan
Yes - There is a plan to make this available
Informed Consent Form
Yes - There is a plan to make this available
Clinical Study Report
Yes - There is a plan to make this available
Analytic Code
Yes - There is a plan to make this available
Data Dictionary
Yes - There is a plan to make this available
Title and more details about the data/document
The results of the exercise intervention and the results of the research will be sent to medical centers and related societies to confirm the best exercise intensity and the effects of improving the obesity process and its complications.
When the data will become available and for how long
the beginning of 1399
To whom data/document is available
Everyone in the community and those interested in health
Under which criteria data/document could be used
In order to use the best method and intensity of exercise and exercise interventions to modify obesity and its pathophysiological complications
From where data/document is obtainable
The documentation of the present research will be published in scientific profiles
What processes are involved for a request to access data/document
By emailing the author or receiving reports from scientific journals
Comments
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