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Study aim
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Investigation the effect of the sumac powder consumption on liver enzymes, lipid profile, glycemic index, inflammatory index and antioxidant index and anthropometric measurements in overweight or obese non-alcoholic fatty liver patients.
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Design
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randomized, double-blind, clinical trial with intervention and control groups
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Settings and conduct
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Patients referring to liver clinic of Motahari clinic, If they meet the inclusion criteria, they will be randomly assigned into two groups. Blindness will be such that supplements and placebo supplements will receive A and B labels and the supplement provider and the patient will not be aware of their condition.
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Participants/Inclusion and exclusion criteria
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Desire to participate in study
Male or female 20-60 years old
Patient who diagnosed NAFLD with using ultrasound by physician
The power of decision making and the ability to do life without the help of others
BMI = 25- 35
No history of alcohol using
No history of liver cirrhosis
Lack of other chronic and acute liver disorders (hepatitis B, C, etc.) and effective hereditary diseases, cancers and hereditary infections affecting the liver (iron storage disease, copper, etc.)
Lack of using of blood lipids, blood sugar, vitamin E and UDCA and hepatotoxic drugs such as phenytoin, amoxifen and lithium.
Lack of celiac disease, diabetes, cardiovascular disease, pulmonary and kidney disease, no history of thyroid problems
No history of weight loss surgery, no recent weight loss plan in 3 months
Lack of supplementation of fiber, omega-3 and antioxidants in 3 months ago
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Intervention groups
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Intervention group: Supplement of Sumac powder (3gr/day)+ diet
Control group: Starch supplement(3gr/day) (placebo) +diet
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Main outcome variables
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Weight,Height,Waist,Hip circumference,Waist to hip ratio,Body Mass Index,Fat Mass, FreeFat Mass, TBW,BCM, Chol,TG, LDL,HDL, FBS ,Insulin,TAC,TNFa, AST/GGT/ALT,ALKP