Effect of Different Levels of Positive End-expiratory Pressure (PEEP) on Respiratory Status during Gynecologic Laparoscopy

Evaluating the Effect of Different Levels of Positive End-expiratory Pressure (PEEP) on Respiratory Status during Gynecologic Laparoscopy

The study protocol was approved by ethics committee of Tabriz University of Medical Sciences. After obtaining informed consent from 60 consecutive women the randomization was done. Anesthesiologist designed the groups stratification via sealed and coded envelope.

The double-blind technique was used to blind both the participants and members of the research teams including principal investigators, surgeons, anesthesiologists, nurses, data collectors, outcome assessors, and manuscript writes.

Inclusion criteria: American Society of Anesthesiologists [ASA] physical status I, aged 18-60 years gynecologic laparoscopy Exclusion criteri: ASA physical status II or more, BMI > 30, systemic diseases including cardio-cerebrovascular, hepato-renal and respiratory disease, psychological disorders, emergency surgery, cigarette smoker, having the history of atopy, refuse to participate.

Consecutive patients were selected based on their entrance. Technique of randomization was performed via randomly permuted blocks using online software (www.randomizer.org). After that, patients were randomized to treatment by 1:1:1 ratio. randomization stratified by online rand list software to three groups: PEEP 0 (ZEEP which receive zero level of PEEP), PEEP 5 ( receive PEEP of 5 cmH2O) and PEEP 10 (receive PEEP of 10 cmH2O).

Base excess; End-tidal carbon dioxide; Bicarbonate; Partial pressure of oxygen; Partial arterial pressure of carbon dioxide; Peripheral capillary oxygen saturation; Potential of hydrogen

Consecutive patients were selected based on their entrance. Technique of randomization was performed via randomly permuted blocks using online software (www.randomizer.org). After that, patients were randomized to treatment by 1:1:1 ratio. randomization stratified by online rand list software to three groups: PEEP 0 (ZEEP), PEEP 5 and PEEP 10.

Double blind technique was used to blind both the participants and members of the research teams including principle investigator, surgeons, anesthesiologist, nurses, data collectors, outcome assessors and manuscript writes.

All the data will be available under the name of supplementary.

All the data will be available after the publication of the article forever

Data will be available to everybody upon request

Data could be used by other researchers for meta-analysis and systematic review

Data will be available as a supplementary file to the published article

The data will be available upon request, forever.