Comparative Evaluation of intravenous Propofol and Midazolam on sedation and nausea & vomiting during spinal anesthesia in cesarean section

Comparative Evaluation of intravenous Propofol and Midazolam on sedation and nausea & vomiting during spinal anesthesia in cesarean section

102 Pregnant women aged 18-46 years undergoing cesarean section undergoing spinal anesthesia will be in double blind randomized clinical trial. in one of the two intravenous administration of 0.2 mg/kg Propofol and 0.02 mg/kg Midazolam.

102 Pregnant women aged 18-46 years undergoing cesarean section undergoing spinal anesthesia who will be referred to the Besat Hospital of Hamadan during the study period, will be randomly assigned to randomized allocation blocks by random sampling. In order to prevent the medication being detectable for patients and investigators, they are prepared and injected into syringes of the same size and shape.

Inclusion Criteria: 18-45 aged pregnant women for C/S; ASA CLASS 1, 2; Satisfaction to participate in the project; Pregnant women who underwent cesarean section under spinal anesthesia. Exclusion Criteria: sensitivity to medications used; Patients who have failed spinal anesthesia and undergo general anesthesia; Lung disease, heart disease, asthma, fever, hypertension, preeclampsia and eclampsia, cardiac arrhythmia; Emergency Cesarean; Eclampsia and Preeclampsia; Multiple pregnancy; Spinal anesthesia contraindications (high ICP, hypovolemia, anemia, coagulation disorders, etc.); History of allergy to eggs, soy, midazolam and propofol; Use of antiemetic drugs

Intervention group 1: The amount of 0.2 mg/kg Propofol intravenously after spinal anesthesia by an anesthesiologist injected intravenously. 2 intervention groups: the amount of 0.02 mg/kg Midazolam after spinal anesthesia by an anesthesiologist injected intravenously.

Sedation score, time to start sedation and duration of sedation, nausea and vomiting

We write two letters A and on two other sheets of letter B. We mix the papers together and put them in the drawer of the table.With each of the qualified patients, one of the papers is taken out randomly and, According to the text, the patient is given one of two groups: A (Propofol) and B (Midazolam). Then, for four subsequent patients, the paper is returned to the bag again, and this process is repeated until the end of the sample volume.

In both groups A and B, medications after spinal anesthesia one of two drugs (Propofol or Midazolam) will be prescribed.In order to prevent the medication being detectable for patients and investigators, they are prepared and injected into syringes of the same size and shape and on the adhesives A and B by the anesthetist. Since drugs are prescribed by an anesthetist, the clinician will not be aware of the type of prescribed medication that will measure and record the outcome of the study.