Comparison of addition of ketamine and dexamethasone to ropivacaine in peritonsillar infiltration to reduce postoperative pain

Comparison of pain and agitation and nausea and vomiting and time and dose of analgesic in rupivacaine plus dexamethasone and rupivacaine plus ketamine

In this double-blind clinical trial study, 5 patients, aged 2 to 4 years, referred to Amir Kabir Hospital, Arak, were diagnosed with tonsillectomy and met inclusion criteria after obtaining informed consent. Patients under study were divided into two groups: dexamethasone and ketamine.

Given the double-blindness, only the primary investigator is aware of the groups and drugs used in this study, and patients and interns are responsible for collecting data from the groups and drugs used. This study was performed in Amirkabir hospital in Arak in 1398 in which all patients underwent tracheal anesthesia after entering the operating room. Then, the interventions are performed by the surgeon and their consequences are statistically analyzed.The extent of pain is determined by VAS ruler at 15, 30 and 2, 4, 8, 16, 24 hours, Agitation was measured by the Riker Sedation-Agitation scale at 15, 30, and 2, 4, 8, 16, and 24 minutes after surgery.

Children between the ages of 3 and 5 years are candidates for elective tonsillectomy in the absence of underlying disease and no history of motion sickness. If surgery lasts more than 2 hours and bleeding exceeds 10 cc / kg, the study will be excluded.

In the first group, the surgeon delivered 2 cc of 0.5% ropivacaine solution plus dexamethasone 0.5 mg / kg (maximum 1 mg) with distilled water to CC 10 and in the second group 2 cc of ropivacaine solution 0.5% plus ketamine 0.5 mg / kg. With the help of distilled water, it reaches CC 10 and is injected into the peritonsillar fossa by the surgeon so that the injection is only in the sub mucus area. 5cm injection is given on each side.

Pain; Agitation

In this clinical trial study, 5 patients, aged 4-5 years, referred to Amir Kabir Hospital in Arak, were diagnosed with tonsillectomy and met inclusion criteria after obtaining informed consent. Patients were then randomly divided into two groups of dexamethasone plus bupivacaine and ketamine plus bupivacaine.

Blindness Due to the double blindness of the study, only the relevant expert in this study is aware of the type of study and study groups, while patients are not aware of the type of drug being used. Also, the intern who is responsible for the design of the checklist is not aware of the groups based on the injectable drug and only identifies the groups based on A and B and fills the checklists accordingly.