Visfatin is an adipocytokines which is secreted from adipose tissue and can be effective on the diabetes inflammatory reaction and also serum lipids level. On the other hand, Omega-3 can reduce the fats and also can prevent form insulin resistance. In the present study, the effect of Omega-3 on the serum visfatin concentration compared with placebo has been reviewed. A total of seventy-one women with type II diabetes in two groups had been under the treatment with Omega-3 capsules and the control group with placebo capsules. In the first step, the study subjects filled in a questionnaire including age, height, weight, waist circumference, hip circumference; besides, their blood sample were taken for the blood tests. In the second step, the intervention was done for 8 weeks and in the third step the above mentioned data and also blood sample were received again. Hip circumference was measured from the middle and the largest part of it and waist circumference also from the cord at the end of a normal exhalation. In the blood samples, the following parameters were measured: visfatin and lipid profiles (LDL: low density lipoprotein, HDL: high density lipoprotein, TG: triglyceride and cholesterol), glucose and HbA1c via a special measuring kit.