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Study aim
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The effect of magnesium sulfate on the prevention of postoperative sore throat in patients undergoing FESS
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Design
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In this study, 90 patients undergoing simple randomized endoscopic sinus surgery were enrolled in a double-blind clinical trial with 45 parallel groups.
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Settings and conduct
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This study was performed at Imam Khomeini Hospital in Ahvaz.
The syringes are pre-prepared, numbered, and coated by an anesthetic technician who has not been involved in the study for blindness.To be a double-blind study, the designer, patient, and registrant of the results will be unaware of the type of injection solution. In recovery, 2, 6, and 12 hours later, the severity of the sore throat (based on the 0-10 criterion) and the incidence of cough is recorded.
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Participants/Inclusion and exclusion criteria
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Patient aged 18 to 60 years
Class I and II by Classification of American Anesthesiology
No pre-operative sore throat
Upper airway infectious disease,
Not having a cold,
Not a smoker,
No liver or kidney failure,
Not to be pregnant,
Magnesium insensitivity,
Should not have been attempted for endotracheal intubation more than once,
Not being in grade 3 or more,
No chronic use of calcium blockers or magnesium
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Intervention groups
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The patient under general anesthesia will be injected with fentanyl 2μg/kg, midazolam 0.02 mg/kg and propofol 2mg/kg and to facilitate intratracheal endotracheal intubation 0.5 mg / kg. Atracurium 0.15 mg / kg is used to continue muscle relaxation if the patient returns.The laryngoscopy will be performed by an anesthesiologist with a metallic laryngoscope No. 3-4. Male patients with endotracheal tube with an inner diameter of 8 and female patients with with an inner diameter of 7.5 mm will be intubated. After intubation, 40 mg / kg magnesium sulfate is injected for 20 minutes at the same volume of normal saline for the control group.
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Main outcome variables
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Sore throat
Cough