Inclusion criteria:
Cancer patients receiving moderate emetogenic chemotherapy regimens,formed the study cohort.
Eligible patients were adults (aged between 18 - 70 years) with a karnofsky index of 50% or more).
Women at reproductive ages should had undertaken an appropriate contraceptive method
Exclusion criteria:
causes of nausea or vomiting unrelated to the chemotherapy (e.g., gastrointestinal obstruction, massive ascites, widespread brain metastases, history of motion sickness or vestibular dysfunction, uremia or electrolyte disturbance)
active infection
uncontrolled seizure
candidate for radiation therapy of brain or upper abdomen in less than a week
an emetic episode 24 h before initiation of chemotherapy
complications that prohibited Dexamethasone use
one of the followings observed in their lab studies : wbc<3000/mm3 , anc<1500/m m3 , plt<100000 mm3, ALT & AST>2.5 * upper limit of normal,Bill & Cr > 1.5* upper limit of normal
opium addicted
poor compliance
receiving corticosteroids for more than 3 months and more than 50 mg Prednisone daily;
Carlson’s comorbidity scale of 3 or more
Any drugs with antiemetic efficacy other than the study drugs wouldn’t been allowed before the study started, and were recorded on.