Comparison of the Effectiveness of 6 mg and 12 mg Adenosine in the Treatment of Paroxysmal Supraventricular Tachycardia

Comparison of the efficacy of 6 mg and 12 mg adenosine in the treatment of supraventricular tachycardia

Clinical trials have two intervention groups, with parallel groups, one-way blind, randomized, and phase 3 on 142 patients. Accidental block method will be used for randomization

In the emergency department of Shahid Rajaei Hospital in Karaj, all patients with dysrhythmia are placed in level 1 triage. In the intervention group 1, a dose of 6 mg is used. In the other group, the treatment will be performed at a dose of 12 mg, and if there is no response, a dose of 12 mg and a Valsalva maneuver will be performed. In both groups, if this treatment is not responded to, the patients will continue to be treated according to the patient's condition. (Using shock or other medications)

Entry requirements: The patient must have informed consent to participate in the study. The patient has a supraventricular tachycardia dysrhythmia. Exit conditions:Patient sensitivity to adenosine, grade 2 and 3 AV node blocks, sick sinus syndrome, history of seizures and previous epilepsy

Patients with a ventricular tachycardia dysrhythmia are placed on first triage level and treated with adenosine.In the intervention 1 group, a dose of 6 mg of adenosine is used first, and in case of non-response, a dose of 12 mg and again, in case of non-response, a dose of 12 mg is used together with Valsalva maneuver and the rhythm of the disc rhythm is recorded.In the intervention 2group, treatments are initially started with a dose of 12 mg adenosine and if the dose is not answered, a dose of 12 mg and a valsalva maneuver will be performed and the rhythm of the disc rhythm will be recorded

paroxysmal Supraventricular tachycardia

Block randomization: In this method, four-letter cards are prepared using A-B letters and one card is selected for each patient. If the first letter is card A, the person will be in group one and if it is B, the person will be in group 2.

In this study, while obtaining conscious consent from the patient or their companions, the participants in the intervention are unaware that they are in the intervention group one or two.In this way, the study participant is unaware of which group is involved and receives the initial dose of 12 mg or 6 mg Adenosine