Comparison of Adaptive Support Ventilation and Synchronized Intermittent Mandatory Ventilation in patients with ARDS: A randomized clinical trial

this study aims to assess the respiratory, arterial blood gas (ABG) and hemodynamic effects of the ASV mode compared to the SIMV mode in patients with ARDS in ICU.

a parallel, randomized controlled trial, phase 3 randomization method: Block randomization. Sample size: 32. consist of two groups receiving intervention 1 and 2.

The protocol of this prospective randomized controlled trial is approved by the Ethics Committee of the Isfahan University of Medical Sciences. 32 eligible patients diagnosed with ARDS who are hospitalized in the ICU of AL-Zahra hospital, Isfahan are enrolled. Patients are allocated into two groups of intervention to receive intervention 1 (SIMV) and 2 (ASV). the mentioned outcomes are measured for 3 days. Lung protection strategies are continued for three days. Statistical analyses are done using SPSS version 23. Different tests are used as necessary and appropriate.

Inclusion criteria: 18-70 years old, expected duration of ventilation >72 hours, no acute renal failure, stable hemodynamic without vasopressor drugs, BMI < 30, acute hypoxemia (P/F ratio <300 mm Hg), and bilateral established infiltration based on chest radiograph. Exclusion criteria: chronic lung disease, pregnancy, smoking, heart failure (EF < 45%), the existence of any brainstem lesions, clinical evidence of left atrial hypertension, and apnea, death, withdrawal from the ICU before 72 hours, and having sepsis.

intervention 1: people with ARDS who receive Adaptive Support Ventilation intervention 2: people with ARDS who receive Synchronized Intermittent Mandatory Ventilation.

Rapid shallow breathing index; Peak inspiratory pressure (cm H2O); Spontaneous breathing rate (breaths/min); Minute volume (L/min)

Using stratified block randomization (stratification was based on disease severity: mild, moderate, severe), eligible patients were randomly allocated into two groups of intervention to receive mechanical ventilation with either SIMV or ASV mode. Random allocation was computerized using specialized Random allocation software.

there is no plan to make this available at the moment.