Comparing the Effects of Vaginal Misoprostol, Vaginal Trinitroglycerin (TNG) and oral Evening Primrose Oil in Cervical Ripening at term pregnancy

Comparison of the effect of misoprostol, vaginal nitroglycerine and capsule of evening primrose evening on cervical ripening in the term pregnancy in Shahid Sayyad Shirazi Hospital in Gorgan

A clinical trial with a control group, with two groups of parallel intervention, a single-blind, randomized, random block method with a sample size of 201

All pregnant women referring to Sayyad-e-Shirazi Hospital of Gorgan, Iran, were studied by single-blind method and the consequences of this study were measured before and 4 hours after prescribing medications. Measurement of the consequences is performed by gynecology resident who is not informed about intervention and control groups.

Inclusion criteria: -Pregnant women (primigravid) -Term pregnancy (40 weeks onwards) -Bishop Score less than or equal to 4 -A candidate for induction of childbirth Exclusion criteria: History of past uterine surgery -Use of intrauterine contraceptives (IUD) -Any medicinal allergy • Developing systemic and localized infection • Developing known diseases such as diabetes, hypertension and... -Existence of any uterine abnormalities.

Intervention Group (A): Vaginal nitroglycerin 400 mg of Zahravi company, a dose of 4 to 6 hours to 3 is administered. Intervention Group (B): Evening primrose Capsules, 1000 mg capsules of primroses (Barij Essence Company with food and drug verification) in a vaginal form every 4 to 6 hours maximum up to 3 doses The control group (C): 25 mcg of a misoprostol tablet (one-quarter of 100 microgram tablets, Abhan Pharmacy) after humidifying the distilled water every 4to6 hours in vaginal form, maximum of 3 doses

Changes in cervix with Bishop score, newborn Apgar score in one and five minutes, length of time from drug to birth, drug side effects, vaginal bleeding rate

The participants were randomly assigned to intervention (A) and Control (B) groups in the study by Block Randomization . That is, by using a dice that has 6 funds, samples are assigned to their groups on any form, and each number is assigned to one of the table blocks, which shows its own state. Group A (vaginal nitroglycerin) and group B (edible capsule primrose evening) and group C (vaginal misoprostol). The complete list of random blocks was presented to the principal researcher by the Epidemiological advisor of the study.

The implementation of this study is a blind one (single blinding). In this study, the assessments of the consequences of the study are blind. So that the principal investigator prescribed the drug and the type of group is informed, but the assessment of the consequences for gynecology resident is not in the current purpose of the study and the type of drugs prescribed.

Only part of the data, such as information about the original outcome, or the possibility of sharing.

Start of access period 6 months after printing results

Only for researchers working in academic and academic institutions

metanalysis and systematic review

investigator through e-mail: sanazalizadehmd@gmail.com

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