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Study aim
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The major purpose of periodontal therapy is to eliminate all bacterial deposits on the tooth surfaces and progression of clinical parameters.Probiotic is a promising treatment method that can be useful as an adjunct treatment to conventional therapy of periodontitis. The aim of this clinical trial is to compare the clinical and bacteriological effects of scaling & root planing with taking placebo or synbiotic product as an adjunct treatment.
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Design
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Interventional, randomized, single blind, Unicenter, with placebo, parallel clinical trial
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Settings and conduct
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Patient were randomly divided into control and intervention groups.Microbiological samples were collected from all patients at baseline and 30 days after treatment and also clinical parameters including pocket depth, clinical attachment loss, bleeding on probing initially and 30 days after treatment, were measured.
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Participants/Inclusion and exclusion criteria
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Inclusion Criteria:
Patient with physical and mental health who were not treated for periodontitis during the last two years, did not use probiotic food products during the past year, who had at least 10 to 12 areas with the pocket depth of 3mm that bleeding on probing.
Exclusion Criteria:
subjects with history of uncontrolled diabetes, AIDS, rheumatic fever, severe hepatic and renal problems, deficiency in immunological and neurological systems, patients consuming any type of medicine that affect periodontal tissue, pregnant and lactating women, smokers and alcoholic patients, subjects a pocket depth of more than 6 mm.
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Intervention groups
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Patient with mild to moderate chronic periodontitis who had at least 10 to 12 areas with the pocket depth of 3mm that bleeding on probing.
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Main outcome variables
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Primary Result: count of Porphyromonas gingivalis in subgingival plaque.
Secondary consequence: evaluation of mentioned clinical parameters