Comparison the effect of oral Clonidine and Tranexamic acid before Surgery on blood loss in lumbar spine surgery

The aim of study is to determine and compare the volume of bleeding and the hemodynamic parameters(Systolic and Diastolic Blood Pressure, Mean Arterial Pressure, Heart rate)during Lumbar Spine Surgery in three groups of Placebo, Tranexamic acid and Clonidine

The clinical trial is randomized, with controlled group, with parallel triple blind groups

Participants of elective neurosurgical patients are selected after evaluating entry and exit criteria and are randomly assigned to receive Placebo, Tranexamic acid and Clonidine. Hemodynamic indices are recorded at the basic time(2hours before surgery), before anesthesia induction, 1,3,5,10,15 min after anesthesia, every 15 min during surgery, in the time of patient enter to the recovery and the volume of blood loss recorded in the end of the surgery

Age between 20 – 65 year;patients who consent to the informed consent to participate;ASA 1,2;do not use Beta blocker and Calcium blocker;do not use of sedative drugs;do not use of Opioids;do not addiction to Alcohol;not allergic reaction to drug;not allergic reaction to Local anesthetic drugs;not history of lumbar surgery;not risk factor of thrombosis;not use of anticoagulants drugs;not use of Digoxin;not use of Aspirin

The first group received 600mg oral Tranexamic acid and one placebo tablet, the second group receive 0/2 mg tablet of Clonidine and 2 Capsules of placebo and the third group receive one tablet of Placebo and 2 Capsules of placebo 2 hours before surgery. All of the patients anesthetized with Midazolam, Fentanyl, Propofol, lidocaine and Cysatracurium, for maintenance of anesthesia we used Propofol and for controlled hypotension Remifentanil with goal of MAP between 80-85 mmHg

Systolic Blood Pressure;Diastolic Blood Pressure;Mean Arterial Pressure;Heart rate

First with attention to the number of groups(3 groups)and the number of persons in every group, explained an amount of six block. So all of the situations that six person can stay on that block and stay on the study in form of couple in one of the triple group. After that randomized selection of the block with table of accidental numbers in fifteen times between all of the form in arrangement have done and fifteen blocks an amount of six selected, that allocated to every group two persons.

We produced Placebo Capsule similar to Tranexamic Acid and Placebo tablets similar to Clonidine. The Tranexamic Acid group received 2 Capsules of Tranexamic Acid and one tablet of Placebo 2 hours before surgery, the Clonidine group received 2 Capsules of Placebo and one tablett of Clonidine 2 hours before surgery, the Placebo group received 2 Capsules of Placebo and one tablett of Placebo 2 hours before surgery. So the patients do not have any information about the intervention and the person who registered the information do not know which patient in which group ist and the study has three blind side.