The purpose of this study was to evaluate the effectiveness of Creating Opportunities for Parent Empowerment (C.O.P.E) program on psychological outcomes and participation of mothers who have preterm infants. Method: Randomized, single blind controlled without placebo, in more than one centre in a city, phase 2-3 trial. Main inclusion criteria: older than 18 years of age, ability to read and speak Persian, infants with: gestational age of 26 to 34 weeks, birth weight of less than 2500 grams, singleton birth, no severe handicapping conditions. Main exclusion criteria: mothers who left the program and did not come back to hospital for more than 4 days. Sample size: 90 mothers Intervention, time and primary outcomes: First phase was hold 2-4 days and second phase 4-8 days after NICU admission. Before every intervention phase, assessments tools were completed and the last evaluation was done 6-12 days post NICU admission. In each session mothers listened to 15 minutes audiotaped information, about preterm infant and they could use this information in written form too. Then mothers answered to 10 post test questions. Finally, mothers were asked to complete each phase's workbooks until the next session. Anxiety and stress were assessed three times and participation assessment was done just one time.