Assessment of E & C vitamins effects on oxidative stress biomarkers, biochemical parameters, Depression, anxiety and stress in workers exposed to noise, cement dust and silica in SHIRAZ cement plant.

The aim is determine the effect of E and C vitamins intervention on oxidative stress biomarkers, biochemical parameters, Anxiety, depression and stress in workers who exposure to cement dust.

Clinical trial study with 2 group include main intervention group that use E and C vitamins and control intervention group that use placebo, Stratified randomized and double blind with parallel group and include 80 participants

Cement dust has many harmful effects on health, So we do this study in Fars cement plant in Shiraz, after choice participant by stratified randomized, Blood sampling perform at the beginning of the work shift at 7 morning. And assessing the oxidative stress level, biochemical parameters before intervention, Also DASS questionnaire filled out. Then vitamins and placebos gives to participants every day along 2 month by our assistant . Researcher and participants not aware of the process of intervention. After two month we will do blood sampling again and will compares the level of oxidative stress, biochemical parameters, with the amount of them before intervention.

Workers with any underlying disease including diabetes, hypertension, heart disease, and kidney disease Workers who take a particular drug or vitamins that has effect on intervention as well as those with less than 5 years job experience Workers who singe a written informed consent

The main intervention group are participants that use E and C vitamins, And control intervention group are participants that use placebo

malondialdehyde, total antioxidant capacity, superoxide dismutase, catalase, silica, alkaline phosphatase, alanine transaminase, aspartate transaminase, high density lipid, low density lipid, triglyceride, total bilirubin, glucose, albumin, creatinine, Anxiety, depression and stress

In this study, because the cement plant consisted of different sections, We chose the stratified randomization method, In this study we have seven units in cement plant and With regard to the number of people in each section we chose our community to participate in this study.After stratified randomization and selection of the total sample size (80)select workers we use flip the coin method to choose participants for intervention and the group of vitamins intervention and placebo intervention will be determined.

In this study we will provide placebo tablet similar to the original tablets content C and E vitamins.Then vitamins and placebos will give to participants by assistant, researcher and participants will not aware of content of tablets.

The data about participants such as main variable can be share after unrecognizable our participants

The time to accesses the information will be four month after publish the results

The information will be available to researchers every where, And we will give the information to people who working in industry.

After do statistical analyses on our information we publish the data in an article, So it will be available for every one.

Individuals can access the article by searching the subjects name that we express, And the article will include the editors email address to answer questions.

After publish the article editor will be online to answer your request, And the process of doing this project and publish article about it has need 8 month nearly