Comparison of the analgesic effect of Magnesium-sulfate and Paracetamol with Paracetamol and Placebo in the treatment of renal colic patients: double-blind clinical trial study

Inclusion criteria:

Individuals who are clinically suspected of having renal colic or have been diagnosed with ultrasound or CT scan with a definitive diagnosis of renal colic Minimum score of 5 from the visual analogue scale(VAS) at baseline Glasgow Coma Scale(GCS) of 15

Exclusion criteria:

Body temperature > 38° C Pregnancy or any doubt about pregnancy Use of pain medication during the last 6 hours Abdominal pain and the possibility of peritonitis Not signing the informed consent Unstable clinical conditions and hypotension(systolic pressure less than 90 or 20% of baseline pressure) and bradycardia(less than 60) and respiratory rate lower than 16 Disposal of stone(s) History of heart diseases History of liver diseases History of kidney diseases History of metabolic diseases History of seizures Drug history of calcium channel blockers History of alcoholism History of mental disorders, depression and recent use of sedative or anti-psychotic or antidepressants History of drug abuse and addiction History of neuro-muscular disease and underlying bradycardia (heart rate less than 60) and long QRS interval History of hypotension History of hypocalcemia and hypomagnesemia Barbiturates and general anesthetics use

Target sample size: 80