Investigation of the effect of intrauterine hyaluronic acid on the prevention of Asherman's syndrome in cases of endometrial injury in patients with septal resection surgery

The purpose of the present study was to investigate the impact of intrauterine injection of hyaluronic acid in the prevention of Asherman's syndrome in patients with endometrial septal resection.

The clinical trial with parallel groups, double blinded, randomized

Subjects are recruited according to the criteria for entering the study from among the patients who are candidates for septal resection referring to Shahid Sadoughi Hospital in Yazd. Patients will be divided into two groups: intervention and placebo, and the random number table are used for randomization. In the intervention group, 1 cc of hyaluronic acid gel is injected, and in the placebo group, 1 cc of normal saline solution is injected as a placebo inside the uterine cavity. Hyaluronic acid and normal saline gels are prepared and coded in the same syringes in the same volume so that neither the patient nor the researcher (the assistant who enters the information in the questionnaire) knows what group the patient is in.

Inclusion criteria: Candidates for uterine septal resin surgery who have suffered endometrial damage during surgery, age 15- 45 years Exclusion criteria: BMI > 35, menopause, pregnancy, cervical cancer, coagulation disorder, infections inside the pelvis, unwillingness for participation in study

In the intervention group, 1 cc of hyaluronic acid gel (humedix- produced in South Korea) and in the placebo group, 1 cc of normal saline solution is injected into the uterine cavity.

Intrauterine adhesions, Asherman's syndrome, menstrual bleeding, number of menstrual days

Simple randomization method with individual unit and Random number table was used for randomization.

Hyaluronic acid and normal saline gels were prepared and coded in similar syringes all with the same volume, and the entire injections were performed by one person (Obstetrics & Gynecology resident). All participants and project executives were blinded to group information; neither the patient nor the researcher collecting the data knew about the type of solution and group classification. Randomization and allocation were concealed from the investigators and study participants until the completion of analyses.