Investigation of the effect of rotarin drug on the symptoms and severity of sore throat in patients with bacterial and allergic sore throats compared with placebo

Determination of the effect of Rotarin drug on the symptoms and severity of sore throat in patients with bacterial and allergic sore throats compared with placebo

Clinical trial study with control group, with parallel groups, double-blind, randomized by simple randomization method using random numbers table, 80 patients, phase 3

In this study, the samples were selected from patients with sore throat who went to the private doctor's office with the Convenience Sampling method and individuals were divided into groups by simple randomization. If patients wish to participate in this research, first the goals and method of conducting the study for patients were explained and then, a written consent was obtained from all volunteer patients. At the beginning of the visit, after recording the severity of the patient's sore throat and completing the quality of life questionnaire, patients were asked to mix 2 sachets of Rotarin in lukewarm water daily for 7 days and drink it in the morning and evening. After 7 days, visit again to record the severity of pain and quality of life questionnaire for each patient. In addition, all patients were asked to take the medication prescribed by their doctor in accordance with the instructions, in addition to taking this herbal medicine.

inclusion criteria: Aged 18-65 years; diagnosis of bacterial and allergic diseases by a physician. Exclusion criteria: Patients' reluctance to participate in the study; Pregnancy and lactation.

rotarian group, placebo group

The severity of the pain; Daily activity

In this study, patients were assigned to two groups of Rotarin and placebo based on a Simple randomization method. This means that all participants had an equal chance of being in each group. The first step is to create a random sequence. For this purpose, we used a table of random numbers. From the beginning, it was decided to go down to read the numbers in the table of random numbers, after selecting the starting point. We then determined that even numbers were assigned to the intervention group and individual numbers were assigned to the placebo group. Due to the fact that when using simple randomization methods, especially in low sample size, it is possible that the two groups do not equal at the same time, so if a group reaches its sample size earlier, then we must ignore the relevant figures, and complete the opposite group. One of the project's colleagues put his finger on a point in the table with his eyes closed, and then, as scheduled, moved down and wrote down the numbers until they reached the sample size in both groups. Each number, depending on whether they were even or odd, represented a group to which we assigned code A (intervention) and B (placebo). With this method, we had a specific sequence of 80 codes A and B at the end, indicating that the first to eightieth person to be included in the study should belong to each group. We wrote the code on a piece of paper in order and put it in an envelope, to use it during sampling. Thus, after reviewing the entry criteria and, if the client wishes, we entered each person into the groups according to our pre-determined list.