لاتين Influence of two regular physical activity interventions on sexual dysfunction and steroid level in female patients with major depressive disorders and undergoing a treatment with SSRIs – randomized interventional study

Influence of physical activity on sexual dysfunction due to SSRIs in female patients with major depressive disorders

randomized ,double blind ,parallel, Clinical trials with control group

After a thorough screening and once a participant is randomized, she completes a brief questionnaire on habitual sexual activity and sexual dysfunction. Thereafter, at baseline, participants complete a series of questionnaires on sexual dysfunction, depression, sleep, psychological functioning, and physical activity. In parallel, experts blind to participants’ group allocation rate participants’ symptoms of depression. Further, blood samples are taken to assess steroids.Such an assessment is repeated at week 6, and week 12 (end of the study). Additionally, at week 3 and week 9, participants rate their sexual dysfunction, depression and sleep complaints.

1. Female, Age between 18 and 50 years, major depressive disorders, SSRI-induced sexual dysfunction,Willing and able to comply with the study conditions,Continuous treatment with an SSRI, Signed written informed Exclusion criteria: 1. Other psychiatric disorders such as bipolar disorders, anxiety disorders, post-traumatic stress disorders, or personality disorders. 2. Pregnant or intending to get pregnant during the period of the study, or breastfeeding; 3. Serious physical impairments such as injuries, surgery recently only recently accomplished, or accidents; 4. Currently under further treatments such as regular physical activity, neuromodulation, or psychotherapy

Intervention 1: Endurance training Intervention 2: Coordinative training Control: without training

sexual dysfunction, Steroids level

Randomization is performed with the software randomization.com, generating at random 3 x 15 assignments/tickets. A psychologist not further involved in the study prepares the 3 x 15 tickets and puts them each in a sealed envelope. All 45 envelopes are put in an opaque box and stirred. Once an envelope is drawn, it is put aside.

In this study, patients in two groups experience different physical activities, and one group will not be active.Therefore,researcher and the clinical caregiver are not aware of the group experience . The investigator of the outcome is also unaware of the group experience .