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Study aim
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The effect of different doses of bolus dexmedetomidine to create controlled hypotension and the incidence of bradycardia in rhinoplasty surgery.
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Design
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This study is randomized clinical trial in which the number of patients is determined according to the sample size formula . The code is given and patients are randomly assigned to three treatment groups, with random code selection.The number of patients is 30 patients.
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Settings and conduct
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In this study, which is performed as a clinical trial in Firoozgar Hospital, patients are randomly divided into three groups after obtaining informed consent. After entering the operating room, all patients are monitored by EKG, NIBP, SPO2 and BIS, and the initial vital signs are recorded. After induction of anesthesia according to the standards, In the first group, dexmedetomidine is injected at a dose of 1 µ/kg for 10 minutes. In the second group, we inject dexmedetomidine at a dose of 9/0 µ/kg , and in the third group, we inject dexmedetomidine at a dose of 8/0 µ/kg. After 5 minutes and also at the end of 10 minutes, the patient's vital signs are recorded and the effect of the intervention on the study variables is investigated.
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Participants/Inclusion and exclusion criteria
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Inclusion criteria: Patients with ASA1 and ASA2 anesthesia score, The average age between 18 and 50 years.
Exclusion criteria: Patient dissatisfaction with participating in the study, Not having blood pressure.
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Intervention groups
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In the first group, dexmedetomidine is injected at a dose of 1 µ/kg for 10 minutes. In the second group, we inject dexmedetomidine at a dose of 9/0 µ/kg , and in the third group, we inject dexmedetomidine at a dose of 8/0 µ/kg.
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Main outcome variables
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Moderate arterial blood pressure, Blood Pressure, Heart rate, Amount of bleeding