Effects of trancecranial direct current stimulation (TDCS) on improvement of obsessive compulsive symptoms, quality of life, depression, and cognitive functions in patients with obsessive-compulsive disorder: A QEEG-Based Study

Determining the effectiveness of TDCS on improvement of OCD symptoms, quality of life, depression, and cognitive functions in patients with obsessive-compulsive disorder

A randomized (using random numbers table), double-blind, sham controlled clinical trial with a parallel group, 30 patients (15 patients in the sham and 30 patients, 15 in each stimulation group).Both participants and evaluators will be unaware of the allocation of study groups.

The statistical population of the present study will include patients with obsessive-compulsive disorder who refer to counseling and psychotherapy centers and psychiatric clinics in Ardabil in 2020. In the stimulation groups (1 mA and 2 mA), the samples will be treated for 10 sessions. Patients will be treated daily for 20 minutes. In the sham group, no therapeutic intervention will be performed with the TDCS device. Patients in both groups will be done pre-tested, post-test and follow up before, after and one month after intervention with Yale Brown, SF-36, Beck-II, Wisconsin cards and QEEG. Control group will be treated with tdcs for 10 sessions after the end of trial.

The research samples will include 45 patients with obsessive-compulsive disorder who will be selected based on the study inclusion/exclusion criteria. Inclusion criteria:Age 18 to 40, literacy to read and write, OCD according to DSM-5 criteria, Willingness to participate in the study Exclusion criteria: Severe mental illness, History of stroke, serious neurologic symptoms including seizures, Brain Surgery, Brain tumor, CSF shunt in the brain, snail planting, physical tools in the body, serious physical illness,

15 in the 1 mA group, 15 in the 2 mA group and 15 in the sham group.

Improvement of OCD symptoms, quality of life, depression, and cognitive functions in patients with OCD disorder

For small studies, random numbers can be used to sort individuals into groups. Persons participating in the research will be given a code or machine number in order to use the random or random numbers table. Since the number of people we want will be selected from 45 people, so the assigned codes and numbers will be double digits. To select sample people from the table, it will randomly start from a table point in the row or column direction. Subjects are then randomly assigned to one of three study groups (1 mA, 2mA and sham) using the random number table and receive intervention in the same group. Each of the 45 selected individuals will be assigned a code between 01 and 45. Because the volume is two digits, 2 digits out of 5 digits (2 digits to the right) will be selected from the random number table, excluding numbers greater than 45 and duplicates. After three groups of 15 are formed, they will be randomly replaced in the 1 mA, 2 mA and sham groups.

In the present study, first the objectives of the study and a whole explanation will be described to the participants and informed consent will be obtained from the participants. None of the participants and evaluators will be aware of the type of stimulation (1 mA, 2 mA and dummy stimulation).

Publication of results of the articles in journals with international indexes

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Dr Behnam Molaei

b.molaei@arums.ac.ir