The effect of curcumin in the prevention of contrast induced nephropathy in patients with moderate kidney failure following coronary angioplasty or angiography

Contrast nephropathy is the most common cause of iatrogenic acute kidney injury. This problem particularly in CKD patients is more common. In various studies, the positive effect of antioxidants in preventing of it is suggested. Therefore, we decided to study the antioxidant effect of curcumin in the prevention of contrast nephropathy in moderate chronic kidney disease patients. All patients with stable angina and unstable or non-ST elevated MI in the of Ghaem and Imam Reza hospital who are candidates for elective and/or emergency coronary angiography or angioplasty enrolled in study, if creatinine more than 1.2 or GFR between 30 to 60 ml / min are based on prior lab tests. It is done as a double blind study for both patients and physicians. 30 patients will be randomly allocated to receive capsule Curcumin 500 mg three times daily from 2 days before angiography until 3 days after it and 30 patients in control group will receive placebo to the same extent. In both groups, from 12 hours before angiography normal saline solution infuse at a rate of 1ml/Kg/hr and it will continue to 12 hours after that. Serum creatinine will be reevaluate in second and third days after angiography. Urinary NGAL will be assessed in the next day of angiography.

Mashhad University of Medical Sciences