Comparison of the effect of Misoprostol and Diplen with Misoprostol in cervical priming in the first and second trimesters

Comparison of the effect of Misoprostol and Dilapen with Misoprostol during cervical preparation in first and second trimesters. Comparison of the effect of Misoprostol and Dilapen with Misoprostrol on cervical dilatation in first and second trimester abortions.

Clinical trial with control group, with parallel group, double-blind, randomized, phase 3, on 196 patients. R random function of R software was used for randomization.

Patients are randomly divided into two groups.The first group of misoprostol is placed 4 hours before surgery and the second group of dilapen is placed 24 hours before surgery and 4 hours before surgery. After general anesthesia, all evaluations of cervical by The blind researcher is done, then the curettage is done and the curettage products are sent for pathology

Inclusion criteria: mothers over the age of 18, a gestational age of less than or equal to 24 weeks based on the date of the last menstrual period (LMP), and an ultrasound of the first 3 months of pregnancy Exclusion criteria: patient dissatisfaction to participate in the study, patients under 18 years of age, contraindications to the use of misoprostol (drug allergy, active asthma, heart disease, renal failure or glaucoma), active genital infection, structural disorders of the uterus and bladder, cancer Cervical and surgical history of cervical cancer

The first group is received for the preparation of cervical dilapine with misoprostol, and the second group is treated with misoprostol

Cervix preparation time Feeling the patient's discomfort based on the five-digit criterion Dilatation and cervical consistency based on the surgeon's examination according to the five-digit criterion

In this study, random allocation of individuals to two groups of intervention and current treatment was performed using Balanced bloch randomization technique. Using R software to generate random number chains 1 to 6 (the number of possible states for placement in blocks) Until the volume of the sample was reached. Preparation of random allocation sequences of individuals and placing them in sealed envelopes (sealed) and numbered with a 5-digit serial number by the third person who plays a role in designing the study. Has not, has been done

In the treatment group, in addition to receiving vaginal diazepam mesoprostol, it is vaginally placed by a specialist doctor, and in the control group, only mesoprostol is received. After the procedure, patients will be examined by 2 blind researchers who do not know to whom dilapen is placed. Who has only used misoprostol. Patients will be examined by two researchers in terms of postoperative complications. The patient will then be hospitalized for side effects after surgery and the consequences of the procedure. The patient's opinion is checked by a student (specific to this task) that the student does not know who received the diplopen and who did not receive it and records all the consequences. In fact, neither the researcher nor the evaluator of the consequences of how patients are divided

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