Comparison of induction of anesthesia with etomidate and propofol on surgical stress responses in spinal elective surgery

Comparison between Induction of Anesthesia with Atomidate and Propofol on Surgical Stress Responses

In this double-blind clinical trials study, 60 patients undergoing spinal surgery were randomly divided into three groups: the first intervention group (recipient of Atomidate) and the second group (recipient of Propofol) and control.

In this study, 60 patients who were candidates for spinal surgery in Golestan Hospital in Ahvaz were selected as available and were divided into three groups of first and second intervention and control in a simple random method. In the first intervention group, 0.3 mg/kg of atomidate and in the second intervention group, 2.2 mg / kg propolis was injected intravenously for induction. The control group also receives routine medications such as sodium thiopental 5 mg/kg. In order to conduct a two-way blind study, patients and researchers who take blood samples do not know which drug groups 1 and 2 and which group received the routine drug.

Inclusion criteria include:Patients are candidates for spinal elective surgery, Lack of bacterial or viral infection, Lack of autoimmune diseases, connective tissue disease, peripheral vascular disease, liver and kidney disorders, heart failure, and mental disorders and Exclusion criteria include: dissatisfaction to continue participating in this study.

In the first intervention group, 0.3 mg / kg of Atomidate and in the second intervention group, 2.2 mg / kg Propofol was injected intravenously for induction.The control group also receives routine medications such as 5 mg/kg sodium Thiopental.

Patients who entered the study, screened for serum IL-1 and IL-6 levels, albumin, glucose, Crp, and cortisone were measured immediately before surgery and anesthesia, 24 hours, 48 hours, and one week after surgery.

Patients were randomly selected and randomly divided into two groups (Atomidate receiver) and the second group (Propofol receiver) through random number tables, so that for the first group, individual numbers were used and for the second group, even numbers were used.

In this study, patients were unaware that they were in the atomidate group or propofol, a person who took a blood sample to check for laboratory tests related to the patient's stress response, and a statistical analyzer who did not know the type of intervention.