Determination and comparison of the effect of 30 and 70 pulses in pulsatile cardiopulmonary bypass on clinical outcome of patients undergoing Coronary Artery Bypass Graft (CABG) surgery

Determination and comparison of the effect of 30 and 70 pulses in pulsatile cardiopulmonary bypass on clinical outcome of patients undergoing Coronary Artery Bypass Graft (CABG) surgery

Randomised ; Controlled ; Unilateral blinded ; Six blocks ; 90 patients

In this study, patients who refer to the operating room of Shahid Rajaei Heart Hospital in Tehran and are on the list of coronary artery bypass graft surgery and have entry criteria are examined. Patients are randomly divided into three groups: group A 30 pulses per minute - group B 70 pulses per minute - group C receives non-pulsating perfusion. All patients under study will have the same anesthesia and pump conditions. After the pump starts and immediately after the aortic clamp, the pulsating current will start, and after removing the clamp, the aorta will end and the pump will continue with the continuous flow.

1. Patient satisfaction to enter the study 2- Patients in the age range of 40-65 years 3- Elective patients of CABG surgery under cardiopulmonary bypass 4. Patients with EF above 30% 5. No history of heart surgery 6- No other processor with CABG 7- Lack of liver failure as ALT> 40 units / l AST> 40 units / l 8. No preoperative pulmonary dysfunction test as FEV1 <65% 9- No creatine level higher than 2 mg/dl 10- Lack of hemoglobin level less than 10 mg/dl

In the pump settings, the A group receives 30 pulse per minute - the B group receives 70 pulses per minute - the C group receives non-pulsating perfusion.After the pump starts and immediately after the aortic clamp, the pulsating current will start and after removing the clamp of aorta will end.

Investigating the amount of liver enzymes; Renal enzymes; Blood lactate; Diuresis; Bleeding rate; Taking inotropic drugs; Long stay at the Intensive Care Unit(ICU)

Allocation of individuals to study groups (interventions and controls) was performed by randomized block method using 6 blocks. This was done with the relevant software by Master of Statistics. In each block there are 2 people related to the control group, 2 people related to the A intervention group and 2 people related to the B group, whose order was random and the blocks were selected using the table of random numbers.

Patients are given explanations about the study and the three groups to be studied, and then they are asked to enter the study, but they are not told which group they are studying.