comparing the effect of two different doses of ondansetron on heart rate , blood pressure and blood oxygen saturation variation in caesarian surgery under spinal anesthesia

determination and comparing the effect of two different doses of ondansetron on heart rate , blood pressure and blood oxygen saturation variation in caesarian surgery under spinal anesthesia

Randomised, controlled , parallel group trial with blinded outcome assessment. Randomisation was centralised and computerised with concealed randomisation sequence carried out at an excel

This study is a randomized double-blind clinical trial that randomization will be done by usind random numbers. this study will be done in Beheshti Hospital.

Age between 18 to 45 years old ASA number 1 and 2 Patient is cesarian candida that term pregnancy Patient has no disease like hypertention Patient has no uncontrolled diabet Patient has no allergy to ondansetron or local anesthtic drug no forbid for spinal anesthesia Patient dosent use drugs which effect on HT35 receptor

Patients will be randomly divided into three groups consist of receiving 6 mg of ondansetron, 8 mg of ondansetron, and distilled water. They are injected intravenously and then the patients are subjected to spinal anesthesia. Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure and arterial blood oxygen saturation are measured and recorded every 15 minutes during surgery and every 15 minutes during the recovery period by an observer who is not by the research team. Any complication is recorded if it occurs during appropriate treatment

Systolic blood pressure, diastolic blood pressure, heart rate, mean arterial pressure, arterial oxygen saturation, nausea, vomiting, duration of surgery,duration of stay in recovery,

In this study ,patients were divided on a basis of Random block making, into blocks consisting of six peoples.in each block, two patients received 8 milligrams of ondansetron, two patients received 6 milligrams of ondansetron, and two patients received normal saline. then by use of Random digits table, 15 different blocks of the so called blocks were randomly chosen. Drugs were drawn in three syringes of the same size and color by an out-of-study anesthesiologist and for every patient proportionate to his group, were given to the main anesthesiologist. Patient, main anesthesiologist, the person in charge of collecting and recording datas were unaware of the Type of the drug that was used.

Drugs were drawn in three syringes of the same size and color by an out-of-study anesthesiologist and for every patient proportionate to his group, were given to the main anesthesiologist. Patient, main anesthesiologist, the person in charge of collecting and recording datas were unaware of the Type of the drug that was used.