The Effect of of Polyunsaturated Fatty Acids on the Nitrosative Stress of Patients Infected With Helicobacter pylori With Dyspeptic Symptoms

Effect of omega fatty acids on nitrosative stress in patients infected with Helicobacter pylori with dyspeptic symptoms

This study is a clinical trial of double-blinded study involving a target population of 34 patients infected with Helicobacter pylori with dyspeptic symptoms. Ping pong balls were used to randomize and assign patients to two control groups (17 people) and intervention (17 people).

n this study, neither the physician nor the patient was aware of the allocation of patients to the target groups, and the method of blinding was random and using ping pong balls. The experiments were done in department of clinical biochemistry of Medical Faculty of Tabriz University of Medical Sciences .The control group received standard therapy and the intervention group received standard therapy plus omega capsules for two weeks. To measure the nitric oxide content of gastric juice in the fasting state, gastric juice was enrolled and the NO amount was measured using the Griess Colorimetric method.

included: presence of peptic ulcer and infedted to H. pylori excluded: In this study people with gastric adenocarcinoma, diabetics, patients with kidney problems, smokers, and patients who had taken omega, fish, drugs, or other medications and supplements three months before entering the study, Were excluded.

The study included two control and intervention groups that, in order to evaluate the effectiveness of omega-3 fatty acids, received the standard therapy intervention group plus omega capsule tablets, and the control group received only the standard therapy. Standard therapy includes clarithromycin, amoxicillin, and metronidazole

Nitric Oxide Reduction of stomach juice in H.pylori infected patients

Write the numbers 1 and 2 in 17 on ping pong balls and pick up the balls by the participants.

Using random numbers The allocation of individuals was done randomly by the researcher and by lottery in case or control groups to avoid possible errors and unwanted orientations. The allocation was made by throwing 34 ping pong balls into a cloth bag, 17 of which were standard therapy + omega capsules, and 17 of which were standard. Each patient who returned to the physician would pick up a ping pong ball, thus identifying the patient group and throwing the balls away after selection.

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