Comparative effect of sufentanil and dexmedetomidin on myoclonus incidence and pain induced by anesthesia with etomidate: a double blin clinical trial study

Evaluation of the effect of premedication with sufentanil and intramedullary doxamethomidine on reducing the incidence of myoclonus and pain due to induction of general anesthesia with otitis media and its comparison with control group

A clinical trial with 3 groups, three randomized blinds is performed on 108 patients.

This study is a double-blind randomized clinical trial with a control group that is conducted in Al-Zahra Educational and Medical Center affiliated to Isfahan University of Medical Sciences in 2018-2019. The target population of the study will be candidates for surgeries admitted to the hospital

۵۲۹/۵۰۰۰ Inclusion and exclusion criteria: A- Entry criteria: 1- Patients 18 to 60 years old 2- ASA class 1 and 2 3- Candidate for surgery and needs general anesthesia 4 - Lack of heart and liver failure, mental illness, neurological diseases, allergies to opioids 5- Not receiving painkillers and sedatives during the last 24 hours 6- Agreeing to participate in the study B- Criteria for not entering: 1. Age less than 18 years or more than 65 years 2. Drug addiction C- Criteria for leaving the study: 1- Lack of cooperation of the person to answer the questions 2- Occurrence of drug allergies 3- 3-change in anesthesia method

The first group was injected with 0.1 micrograms per kilogram intravenously and the second group was injected with 0.5 mg / kg dexmedetomidine intravenously Special is done.

Medium arterial pressure Myoclonus recovery the pain Spo2

Eligible additions were assigned to the three study groups using randomized block methods with a size of 6 blocks and using random allocation software.

In the present study, the injector and the data collector also had no information and the participants did not know the type of drug received. The injector has no knowledge of the type of drug (blinding) and the data collector has no knowledge of the type of drug (both sides of the blind). Premedication drugs are coated in 10 ml syringes with prior coding. After administering 100% oxygen, premedication is given intravenously over a period of 2 minutes. The second anesthesiologist, who is not aware of grouping, then records the myoclonus movements and pain of the patients based on scoring. The first anesthesiologist injects only medications and collects information such as pain and myoclonus, mean arterial pressure, heart rate, blood oxygen saturation percentage at the general time 0, 5, 10, 15, 30, and 60 minutes after atomiditis. They do not have any information about the type of medicine they received.