After selecting the volunteers, Riluzole drug manufactured by Hooger Daru Company from Iran and by Sanofi Aventis Company of France will be prescribed to them orally in two doses with an interval of 7 days. For example, if in the first period of the drug administration, the volunteer received the drug manufactured by Hooger Darura, in the next turn, the volunteer will receive the drug manufactured by Sanofi Aventis. Each time the amount of 6 cc of blood before drug administration and at times of 0.25, 0.5, 0.75, 1, 1.25, 1.5, 2, 4, 6, 8, 12, 16, It will be taken from the volunteers 24 and 48 hours after the medication is prescribed. The next sampling will 7 days later. In the second time, similar to the first time of drug administration, blood sampling will be done. In the next step, the serum and plasma of each sample are separated by centrifuge and the amount of drug in each sample is determined by liquid extraction method and using Lc Mass Mass.
The study will be done in Hezareh Sevom Futuristic Pharmacist company