Effect of intravenous Dexamethasone on prevention of complications of laryngeal mask airway (LMA) in inguinal region surgeries

Determination of the effect of intravenous Dexamethasone in the prevention of Laryngeal Mask Airway(LMA) complications including nausea&vomiting,sore throat,cough& chills in inguinal surgeries.

Clinical trial with control&intervention groups,with parallel groups,double blind,randomized,phase3 on140 patients.Patients will be assigned between 2groups using a random quadruple block method.

In this study,a sample of 140 patients who are candidate for inguinal region surgery and will have general anesthesia with classical LMA in Imam Reza, Imam Khomeini and Fatemi hospitals in Ardabil, is selected.Patients will be assigned between 2groups using a random quadruple block method and It is double-blind. Except for the executor of the project, the rest, including patients and clinical caregivers and evaluators and analyzers, will be unaware of the type and amount of medicine. Group1:After establishing the airway,Dexamethasone 8mg/IV/stat will be injected. Group2:After establishing the airway,Normal Saline 2cc/IV/stat will be injected. After the operation,in recovery and also 2&4 hours after the operation,patients are examined for complications ,and recorded.Finally,they will be analyzed.

Patients who are candidate for inguinal surgery and will have general anesthesia with classical LMA are selected. If the patient is not satisfied or American Society of Anesthesiologists greater than or equal to3, he/she will not enter the study.

Intervention group(70 patients) will have general anesthesia with LMA.After establishing the airway,Dexamethasone 8mg/IV/stat will be injected. Control group(70 patients) will have general anesthesia with LMA. After establishing the airway,Normal Saline 2cc/IV/stat will be injected.

Nausea&vomiting;Cough;Sore throat;Chills;Odynophagia;Dyspnea;Epigastric pain

. In terms of random allocation, patients will be assigned between two groups using a random quadruple blocks method. Thus, we will create blocks A, B, C and D and it will be randomly assigned to the relevant groups (Dexamethasone group and control group). The blocks are pre-prepared and randomly assigned to the control group and the Dexamethasone group. Except for the executor of the project, the rest, including patients and clinical caregivers and evaluators and analyzers, will be unaware of the type and amount of medicine.

In terms of blinding, Dexamethasone and Normal Saline will be given to the anesthesia technician in ready-made syringes and will be injected in order of quadruple blocks.In terms of outcomes measurement, the assessor will measure the studied variables and he will be unaware of the classification of the group receiving Dexamethasone or Normal Saline. Except for the executor of the project, the rest, including patients and clinical caregivers and evaluators and analyzers, will be unaware of the type and amount of medicine.