-
Study aim
-
Evaluation of Intravenous Hypertonic saline infusion in treatment of patients with Diuretic Resistant Generalized Edema
-
Design
-
This is a randomized, double-blinded clinical trial performed on patients admitted to Imam Hossein Hospital.All participants were evaluated carefully with clinical history,
physical examination.
Fasting blood samples were drawn to determine serum levels of Na, K, Cl,
creatinine, urea, Urinary osmolarity and C-cystatin before and 48 hours after treatment.
The body weight of patients assessed in the morning, Digital Scales,before
and 48 hours after management.
-
Settings and conduct
-
The first one intervention group received 150 ml of hypertonic sodium 3% and 250 mg of furosemide every 12 hours for 48 hours and the second placebo group received normal serum saline 0.9% instead of hypertonic. The change in the Body weight, urine output, blood pressure, uric acid, Urine osmolarity, blood biochemistry features and C-cystine levels were assessed.
-
Participants/Inclusion and exclusion criteria
-
The target population for this trial was patients older than 18 years old with diffuse peripheral edema who did not respond adequately to receive 80 mg of furosemide
. Subjects candidated of hemodialysis, systolic pressure ≤80 mmHg, GFR ≤15, serum albumin ≤2.5, serum potassium ≥5.5, serum sodium more than 145, and anuric patients (urine volume ≤100 ml per 24 hours)،Patients with comorbidities, as dementia, cerebral vascular disease and inability to give informed consent were excluded, as were patients requiring pacemaker implantation and those with a substance or alcoholic addiction.
-
Intervention groups
-
patient with generalized resistant to duretic edema who will undergo treatment with 250 mg fursomide plus 150 cc 3%saline q 12h for 48h
-
Main outcome variables
-
weight
c-cystatine