Many studies have been carried out regarding the effect of l-arginine supplementation on physical performance and blood lactate levels in athletes, but the result are contradictory.The aim of this study was to determine the effect of l-arginine supplementation on exercise performance and blood lactate levels in athletes. Thirty healthy male athletes were enrolled and randomly divided in two groups in a single blind placebo-controlled trial. Subject performed exercise test before and after intake of l-arginine (5 g per day) or placebo for a period of 3 weeks. The exercise tests were carried out by the time anaerobic threshold was reached by conconi protocol on treadmill. Three blood samples for measurment of blood lactate were obtained before exercise test, at the end of exercise test, and 30 minutes after the end of exercise. the indexes of exercise performance such as VO2max, distance, time, energy expenditure and heart rate in anaerobic threshold can be measured by conconi test.
General information
Acronym
IRCT registration information
IRCT registration number:IRCT201009064703N1
Registration date:2010-09-08, 1389/06/17
Registration timing:retrospective
Last update:
Update count:0
Registration date
2010-09-08, 1389/06/17
Registrant information
Name
Alireza Moazzezzaneh
Name of organization / entity
Tehran University of Medical Sciences
Country
Iran (Islamic Republic of)
Phone
+98 21 6637 7435
Email address
moazzez_a@yahoo.com
Recruitment status
Recruitment complete
Funding source
Tehran University of Medical Sciences
Expected recruitment start date
2009-01-20, 1387/11/01
Expected recruitment end date
2009-02-10, 1387/11/22
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Effect of L-Arginine supplementation on exercise performance and blood lactate levels in athletes
Public title
Effect of l - Arginine supplementation in athletes
Purpose
Other
Inclusion/Exclusion criteria
Inclusion criteria:
1- sex: man
2- no intake of l- arginine supplement or other supplements
3- no intake of drugs
4- to be athlete
Exclusion criteria:
1- intake of supplement or doping drugs
2- intake of drugs
3- intake of l - arginine supplement
4- have a medical problem
Age
From 20 years old to 25 years old
Gender
Male
Phase
N/A
Groups that have been masked
No information
Sample size
Target sample size:
30
Randomization (investigator's opinion)
Randomized
Randomization description
Blinding (investigator's opinion)
Single blinded
Blinding description
Placebo
Used
Assignment
Parallel
Other design features
Secondary Ids
empty
Ethics committees
1
Ethics committee
Name of ethics committee
Tehran University of Medical Sciences
Street address
Keshavarz Boulevard, Tehran
City
Tehran
Postal code
Approval date
empty
Ethics committee reference number
4229
Health conditions studied
1
Description of health condition studied
Physical activity in athletes
ICD-10 code
-
ICD-10 code description
-
Primary outcomes
1
Description
blood lactate
Timepoint
before exercise test, immediately after test and 30 minutes after test in day 1 and day 21
Method of measurement
lactometer, mmol/l
2
Description
energy at anaerobic threshold
Timepoint
day 1 and day 21
Method of measurement
treadmill, kcal
3
Description
distance to reach anaerobic threshold
Timepoint
day 1 and day 21
Method of measurement
treadmill, meter
4
Description
time to reach anaerobic threshold
Timepoint
day 1 and day 21
Method of measurement
treadmill, s
5
Description
heart rate at anaerobic threshold
Timepoint
day 1 and day 21
Method of measurement
treadmill, beats per min
6
Description
VO2max at anaerobic threshold
Timepoint
day 1 and day 21
Method of measurement
treadmill, ml/min/kbw
Secondary outcomes
1
Description
body mass index
Timepoint
day 1 and day 21
Method of measurement
kg/m2, calculate
2
Description
weight
Timepoint
day 1 and day 21
Method of measurement
INBODY3, kg
3
Description
lean body mass
Timepoint
day 1 and day 21
Method of measurement
INBODY 3, Kg
4
Description
fat mass
Timepoint
day 1 and day 21
Method of measurement
INBODY 3, Kg
Intervention groups
1
Description
Intervention:
Intake of l - arginine (5 g per day) for a period of 3 weeks. time of intake: 2 h after dinner.
Category
Treatment - Drugs
2
Description
Control:
Placebo (5 g per day) such as starch tablets for a period of 3 weeks. time of intake: 2 h after dinner.
Category
Treatment - Other
Recruitment centers
1
Recruitment center
Name of recruitment center
National Olympic Academia
Full name of responsible person
Dr Seyed Ali Keshavarz, professor, Nutrition and Biochemistry group, Tehran University of Medical Sc
Street address
Seol st.,
City
Tehran
Sponsors / Funding sources
1
Sponsor
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Dr Seyed Ali Keshavarz
Street address
Tehran University of Medical Sciences, Nutrition and Biochemistry Group
City
Tehran
Grant name
Grant code / Reference number
Is the source of funding the same sponsor organization/entity?
Yes
Title of funding source
Tehran University of Medical Sciences
Proportion provided by this source
100
Public or private sector
empty
Domestic or foreign origin
empty
Category of foreign source of funding
empty
Country of origin
Type of organization providing the funding
empty
Person responsible for general inquiries
Contact
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Dr Ali Akbar Saboor Yaraghi
Position
Assistant professor, Nutrition and Biochemistry group
Other areas of specialty/work
Street address
Keshavarz Boulevard, Tehran University of Medical Sciences, Nutrition and Biochemistry group
City
Tehran
Postal code
Phone
+98 21889739014
Fax
Email
Saboor_A@yahoo.com
Web page address
Person responsible for scientific inquiries
Contact
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Dr Seyed Ali Keshavarz
Position
Professorr of Nutrition and Biochemistry group
Other areas of specialty/work
Street address
Tehran University of Medical Sciences, Nutrition and Biochemistry group
City
Tehran
Postal code
Phone
+98 21889739014
Fax
Email
S_Akeshavarz@yahoo.com
Web page address
Person responsible for updating data
Contact
Name of organization / entity
Tehran University of Medical Sciences
Full name of responsible person
Alireza Moazzezzaneh
Position
MSc
Other areas of specialty/work
Street address
Tehran University of Medical Sciences, Nutrition and Biochemistry group
City
Tehran
Postal code
Phone
+98 21 6637 7435
Fax
Email
moazzez_a@yahoo.com; alireza_muazzez@yahoo.com
Web page address
Sharing plan
Deidentified Individual Participant Data Set (IPD)