Comparative study of the effect of Haloperidol and Dexmedetomidine on delirium and agitation in mechanically ventilated patients following concussion admitted to the intensive care unit

Comparison of the effect of Haloperidol and Dexmedetomidine on delirium and agitation in patients under mechanical ventilation following concussion admitted to the ICU

In this double-blind clinical trial study, 60 mechanically ventilated patients in the intensive care unit were randomly divided into intervention groups 1 and 2.

In this study, 60 patients under mechanical ventilation admitted to the ICU of Imam Khomeini Hospital in Ahvaz were selected by convenience sampling and randomly divided into two intervention groups 1 and 2. Patients in intervention group 1, in addition to routine care for 7 days, 2.5 mg of haloperidol in bolus and then 0.5 - 2 mg/h and patients in group 2, 1μg/kg of bolus dexmedetomidine and then 0.2-0.7 μg in Kg/h was injected by infusion. In order to blind in this study, the patient caregiver and statistical analyzer were unaware of the type of intervention.

Inclusion criteria include: Patients 18-65 years old with traumatic brain injury APACHE II criteria more than 48, RASS criteria between +1 to +4, At least 48 hours after ICU admission. Exclusion criteria include: Dissatisfaction of the patient's legal guardian, Patients who are candidates for surgery, Unstable hemodynamic status, History of mental illness or use of neuroleptics, History of drug use any contraindications to dexmedetomidine or haloperidol (allergy, arkinson's, hypotension, bradycardia), Kidney or liver dysfunction

In addition to routine care, for 7 days, Patients in the first group will be injected with 2.5 mg of haloperidol as a bolus and then 2.5-5 mg/h as an infusion of haloperidol. Micrograms per kilogram per hour will be infused with dexmedetomidine.

Delirium level, agitation rate, length of hospital stay, duration of mechanical ventilation and need for sedation

Patients were selected by convenience sampling and divided into two intervention groups 1 (Haloprodil recipient) and intervention 2 (Dexmedtomidin recipient) through a random number table with even numbers assigned to intervention group 1 and odd numbers for intervention group 2. In this way, the first even number was assigned to the first patient of intervention group 1 and the first odd number to intervention group 2, and the even and selected numbers were selected and grouped from the table of random numbers of patients, respectively.

In this study, the nurse and patient caregiver did not know which group of patients the intervention group was in and whether the researcher was receiving Haloperidol or Dexmedetomidine in the ward, and the statistical analyzer was also unaware of the type of groups.