Comparison of the effect of Clindamycin suppository and Lactobacilli suppository in vaginal microbiome on in-vitro fertilization (IVF) in patients candidate for embryo transfer referring to Omid clinic, Hamedan: single blind randomized clinical trial

To compare following variables in different study arms: number of embryos and oocytes, quality of embryo, age of parents, uterous anomaly, method of embryo transfer, traumatization, ET difficulty, fertilization rate, implantation rate, preterm labor, PROM, early abortion with FHR, early abortion without FHR, chemical pregnancy, life birth rate in different study arms (clindamycin suppository-lactobacilli suppository-placebo)

Clinical trial with placebo group, with parallel groups, single-blinded, randomized with permuted block randomization with sample size of 108 patients

All patients candidate for IVF referring to Omid clinic, Hamedan, Iran are enrolled in this study. Patients who are enrolled in the study will receive treatment by a care provider who is blinded to the type of drugs.

Inclusion criteria included patients candidate for IVF referring to Omid clinic, Hamedan, Iran. Exclusion criteria included poor responder patients and those with severe male infertility

Clindamycin suppository, Lactobacilli suppository, Placebo

Implantaion rate, PROM, Abortion, Life birth

we used permuted block randomization in this study. patients were randomly assigned to 3 blocks (each containing 6 persons).

Patients who are clinically asymptomatic will be enrolled in the study and receive treatment by a care provider who is blinded to the type of drugs

data for the method of RCT and primary outcome will be published

6 months after publish of results

people working in academic institutions

after sending the research proposal, data will be available

via email : anvar_anvari@yahoo.com

access to the data will be available as soon as possible after reading the research proposal