Comparative study of the combination of "dimenhydrinate with metoclopramide" and "dimenhydrinate with ondansetron" with "dimenhydrinate alone" in the prevention of nausea and vomiting after cataract surgery under local anesthesia

Determining and comparing effect of the combination of "dimenhydrinate with metoclopramide" and "dimenhydrinate with ondansetron" with "dimenhydrinate alone" in the prevention of nausea and vomiting after the surgery

A randomized double-blinding clinical trial, with the parallel groups

This randomized double-blind clinical trial is carried out at Feyz Hospital in Isfahan. In this study, 160 patients who are candidates for cataract surgery will be admitted and randomly divided into 4 parallel groups. The distilled water, dimenhydrinate-metoclopramide, dimenhydrinate-ondansetron, and dimenhydrinate alone will be prescribed for these four groups half an hour before the induction of anesthesia, respectively.

Inclusion criteria include candidates for cataract surgery, the ASA I, II, or III, and stability of hemodynamic status. Exclusion criteria include the history of the motor disease, addicted patients, smoking, allergies to studied drugs, liver, and vestibular disorders, the use of antinausea drugs in the last 24 hours, prolonging the surgery more than 45 minutes.

Half an hour before induction of general anesthesia (which includes injection of 1 cc of 1% propofol, 1 μg/kg and 0.15 mg/kg of ketamine) in the control group 2 cc of distilled water, in the first intervention group 0.5 mg/kg dimenhydrinate with 0.1 mg/kg metoclopramide, in the second intervention group 0.5 mg/kg dimenhydrinate with 0.4 mg ondansetron and in the third intervention group 0.5 mg/kg dimenhydrinate will be administered alone.

Severity of nausea; Severity of vomiting; pain intensity; patient satisfaction

160 eligible patients will be simple randomly easily selected. Then, these patients will be randomly encoded using computer software called "Random Allocation" and automatically divided into four groups. The relevant codes will be entered in the raw checklists and each of these checklists will be randomly assigned to one patient and that patient will be randomly assigned to one of the four study groups.

To blind the study, the drugs will be prepared by an anesthesiologist before the intervention. In terms of the amount of the drug, all drugs will be reached the same volume using distilled water. These syringes will be coded and placed in the operating room and delivered daily to the anesthesiologist, who will prescribe them without knowing the type of medication. Also, the person recording the clinical and basic information of the patients as well as the statistical analyst will not be aware of the type of intervention.

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