Investigating the effect of low dose vitamin D on intensity of dysmenorrhea

Determining the intensity of dysmenorrhea pain in the two intervention and control groups before, immediately, 1, 3 and 6 months after the intervention

Double Blind Randomized Placebo Controlled Trial

Participants will be recruited via convenience sampling by referring to different faculties of Qazvin University of Medical Sciences. eligible people with the desire to participate in the study are registered. Then random allocation in two groups will be done by balanced block randomization method with block size of 4. Participants, researchers, outcome assessors, and data analysts will be blinded to the study groups.

Inclusion criteria: 1. Moderate to severe primary dysmenorrhea (score higher than 4 based on visual pain scale) 2. Single 3. At reproductive ages (18 to 35 years) 4. Student of Qarvin University of Medical Sciences 5. Willingness to participate in the study Exclusion criteria: 1. Existence of secondary dysmenorrhea and its predisposing factors such as history of endometriosis, adenomyosis, subacute endometritis, pelvic inflammatory disease, copper intrauterine devices, ovarian cysts, congenital pelvic malformations and cervical stenosis based on individual statement. 2. History of known mental illness based on individual statement 3. Drug addiction based on a person's statement 4. Probability of graduation during the follow-up period 5. Use vitamin D or calcium supplements 6. Concomitant use of corticosteroids, anticonvulsants, anti-tuberculosis, anti-hypertensive drugs that interfere with the absorption of vitamin D

Intervention group with vitamin capsule 1000 units / control group with placebo capsule

Intensity of dysmenorrhea pain

Individuals will be assigned to intervention groups and placebo by block randomization method using 4 blocks. Given that the two groups will be studied, blocks with size of 4 are used and each letter is assigned to a group (A: intervention group, B: comparison group). All possible modes are written and numbered for a block of 4, such as: 1.AABB 2.ABAB 3.BBAA 4.BABA 5.ABBA 6.BAAB 7 .--- Then, in a simple random method (using a table of random numbers), a number of numbers are selected from the block numbers and by writing the contents of the blocks related to those numbers (until the specified sample size is obtained), The random assignment sequence is specified. For example, if the numbers obtained are 3, 2, 2, 1, etc., respectively, the assignment sequence will be as follows: AABB ABAB ABAB BBAAThe type of intervention is then written based on the allocation sequence and placed in envelopes in a matte package. The envelopes are coded in order. In this case, for the person who receives the intervention code 1, a questionnaire with the same code is completed.

Blinding of medicine and placebo capsules will be done by the pharmaceutical company. The drug and placebo will be similar in shape, color and smell and will be provided to the researcher with the code a, b. The participant, researcher, outcome assessor, and data analyst will be unaware of the codes until the end of the analysis. At the end of the analysis, codes specific to each group will be taken from the pharmaceutical company.

Participants' personal data is shared in an unidentifiable manner along with the publication of the final article

After the completion of study

there is no limitation

there is no limitation

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