Effect of co_administration of vitamins A and D on symptoms in patients with pneumosepsis: a randomized clinical trial

Clinical trial of effect of coadministration of vitamins A and D on symptoms in patients with pneumosepsis.

Blocked randomized, double blind, clinical trial study, single center, controlled placebo, sample size 80 patients selected in 6 months and block randomized into four groups.

A randomized, double-blind (Patients will be unaware of the type of intervention, The analyzer will be unaware of the type of interventions ) clinical trial study, single center, 80 Samples selected via patients with pneumosepsis referred to the Valiasr, Amiralmomenin, Amir Kabir and Khansari Hospitals of Arak in 6 months and block randomized into four groups.

Age greater than 18 years old; sepsis diagnosis and infection source. Non-inclusion criteria: Vitamin D intake during 7 days ago; History of parathyroid diseases; End stage renal disease (ESRD)

First (intervention) group receive, 300000 unit vitamin D (1 milliliter), Intramuscular (IM) with 50000 unit vitamin A (1 milliliter), Intramuscular (IM) as a single dose. The second group (intervention) receive, 300000 unit vitamin D (1 milliliter), Intramuscular (IM) as a single dose. The third group (intervention) receive, 50000 unit vitamin A (1 milliliter), Intramuscular (IM) as a single dose. The fourth group (control) receive, 2 milliliter normal saline as placebo, single dose, intramuscularly.

Vital signs, arterial blood oxygen, WBC, Cr, ESR, CRP, Serum uric acid level, Serum urea level

In this study the randomization will be done using block randomization method. In order to allocate the patients randomly into Intervention and control groups, at first 10 blocks of size 8 with C and T letters (The letters indicate the intervention and control groups) are created. Then the blocks are randomly selected and arranged to obtain a sequential combination of 80 letters. Each letter will be placed in a sealed packet according to the obtained sequence.

patients will be unaware of the type of intervention. The analyzer will be unaware of the type of interventions. Therefore, the trial will be run as double blind.