Comparison of the analgesic effect of intrathecal dexmedetomidine versus fentanyl in opioid dependence undergoing lower limb orthopedic surgery

Comparison of the effect of intrathecal dexmedetomidine and fentanyl on postoperative analgesia in opioid patients during orthopedic lower limb surgery on postoperative pain

A Clinical trial of 25 patients with three treatment paralll groups (receiving fentanyl and dexmedetomidine and normal saline added to spinal bupivacaine), double-blind, randomized using Random allocation software

The spinal anaesthesia will be performed in a sitting position by an anesthesiologist . Patients will be randomly divided into 3 groups (25 people). Then, hemodynamic parameters of patients in addition to baseline values ​​at times 2,5,14,15,24 minutes and then measured every 14 minutes to an hour as well as 2 times in recovery and will be recorded.

Drug-dependent patients 18-65 years with ASA II, I Candidate for lower limb orthopedic surgery under spinal anesthesia Exclusion criteria:Emergency surgery, patients with severe valvular heart disease Patients with psychological disorders,Patients with a history of seizures,Patients with ASA greater than II,Patients with allergies to prescription drugs,Patients with a ban on spinal anesthesia (coagulation problems, high ICP, sepsis, infection at the injection site),Patients with neurological defects, Patients who fail the block and need to induce general anesthesia.

The first group will receive 12.5 mg bupivacaine 0.5% hyperbaric with 5 micrograms Dexmedetomidine The second group will receive 12.5 mg bupivacaine with 25 micrograms fentanyl The third group will receive 12.5 mg bupivacaine and 0.5 cc normal saline

The severity of postoperative pain

Random allocation was performed based on Random allocation software and based on that even numbers were considered for dexmedetomidine and odd numbers were considered for fentanyl accordingly. The numbers were placed in sealed envelopes and returned by someone other than the procedure performer. Anesthesia was performed by an anesthesiologist and anesthesia resident in charge of data collection and the patients both did not know about the injectable drug and how it was randomized.

In order to eliminate bias from patient's awareness or anesthesia assistant and person who evaluate the results and its possible impact on the outcome of the study, the study will be conducted in a double-blind condition. After receiving written informed consent from patients, spinal anesthesia was done by anesthesiologist, then relevant information was recorded in the questionnaire by the anesthesiologist who was not aware of the injection of the drugs. It is obvious that the patient and the anesthesiologist were not aware of the type of drug being administered.

All data can be shared

Starting the post-access period of the paper was accepted

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Correspondence Dr Hashim Jarineshin contact by email hjarineshin@yahoo.com

Details are available within a week at most