Comparative study of intravenous injection of pethidine and dexmedetomidine to prevent shivering after cesarean section under spinal anesthesia

Determining the effect of intravenous injection of pethidine and dexmedetomidine to prevent shivering after cesarean section under spinal anesthesia

A randomized double-blinding clinical trial, with the parallel groups

This randomized double-blind clinical trial is performed in Al-Zahra and Shahid Beheshti hospitals in Isfahan. In this study, 90 pregnant women will be candidates for elective cesarean section and will be randomly divided into 3 parallel groups. The three groups were then given normal saline, dexmedetomidine and pethidine, respectively, immediately after anesthesia.

Inclusion criteria include pregnancy, elective cesarean section with ASA score 1 and 2, not addicted to drugs and alcohol based on the patient's statement. Exclusion criteria include previous use of painkillers, drugs and alcohol, history of severe cardiovascular disease, History of kidney and liver diseases, presence of drug allergy, seizures, and Having fever.

A 15 ml/kg of lactated ringer is injected for All patients, which has reached a temperature of 37 ° C. Oxygen is applied with a flow rate of 5 liters/minute, and patients are covered with a thin coating that does not actively warm them. The room temperature is kept at 24 ° C and there is no heating device there. Spinal anesthesia is performed in the lateral decubitus position of the and at the L3 and L4 levels in the midline after the umbilical cord clamp. The patients are placed in the supine position with some rotation to the right. Then, patients in the control group, first and second intervention groups, were given the normal saline, 1 μg / kg dexmedetomidine, and 0.25 mg of pethidine respectively.

Tympanic temperature (as central temperature); Axillary temperature (as the peripheral body temperature); Intensity of shivering

In order to meet blindness, the drugs will be prepared by an anesthesiologist before the intervention. In terms of the amount of the drug, all drugs will be reached the same volume (3 ml) using distilled water. These syringes will be coded and placed in the operating room and delivered daily to the anesthesiologist, who will prescribe them without knowing the type of medication. Also, the person recording the clinical and basic information of the patients as well as the statistical analyst will not be aware of the type of intervention.

There is no further information