Effect of prophylactic intravenous tranexamic acid on blood loss after cesarean delivery

The aim of this study was to evaluate the effect of preventive injection of tranexamic acid ampules on blood volume lost after cesarean delivery.

In practice, the volume of blood in the suction (the volume of amniotic fluid from the blood that has accumulated in the suction) and the weight of the gauze and blood-stained tampons will be used to check for postpartum hemorrhage. A perfectly wet 4 x 4 cm gas holds about 10 cc of blood (28). A digital scale (with an error rate of 10 grams) will be used to weigh gases and guns. Postpartum hemorrhage is defined as a person losing 1,000 cc or more of blood after a cesarean section. To collect the blood lost after the cesarean section, immediately after the end of the cesarean section, a disposable plastic cover with a certain weight is spread under the cesarean section woman and she will be weighed 2 hours after the cesarean section.

The study population included women eligible for cesarean section in Izadi Hospital.

Inclusion criteria included age 18-35 years, single pregnancy, cesarean delivery, blood pressure less than 140 over 90, no history of thromboembolism, no uterine myoma, no IUFD fetus, no decolonization and no history or active heart disease , Hepatic and renal. During cesarean section, if placental adhesions such as placenta, increta and percorta are observed, individuals will be excluded.

The case group received 10 mg / kg tranxamic acid ampoule (made by Kharazmi Company) by slow intravenous injection (1 cc / min) immediately before cesarean section and the control group received intravenous sodium chloride (distilled water) ampoule at the same dose as the intervention group. Will receive.

Lost blood volume and hemoglobin and hematocrit levels before and 12-24 hours after delivery

The research population is randomly divided into two groups of intervention and control. Random assignment of patients to two groups is based on the block method. Block size 4 is considered. So we have six quadruple blocks consisting of AABB, ABAB, BBAA, BABA, ABBA, BAAB. The selection of each block will also be random and will be done using dice. For example, if the number 3 is rolled in a dice, the BBAA block is considered, so the first two patients are assigned to treatment B and the next two patients to treatment A. The dice will be thrown ten times to complete the assignment of patients to treatment groups. Assignment of treatment to groups A and B will also be based on accident (coin toss).

In order to hide the medication allocation, two vials of the tranexamic acid and distilled water were placed in similar opaque sequentially numbered sealed packages by an Operator room technician that not involved in sampling and analysis, who maintained the medication administration code. In this way, the data evaluators and participants had no knowledge of the study medication.

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