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Study aim
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The effect of zinc supplementation on the serum level of leptin, ghrelin, C-reactive protein and anthropometric indices in obese individuals with increased appetite and zinc deficiency
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Design
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Placebo controlled clinical trial, double blinded randomized ,on 50 individuals were randomly allocated to either zinc or placebo groups Blocked randomization(within fixed block size of four) produced by random allocation software.
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Settings and conduct
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People who referred to nutrition ward of Imam Reza Clinic in Shiraz,Iran were screened to find eligible participants and after obtaining written informed consent, to determine the serum zinc concentration, blood samples were collected, and only those with serum concentration less than 70 mcg/dl were considered to participate in the study.
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Participants/Inclusion and exclusion criteria
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Age 25-55 year
Serum zinc less than 70 microgram/deciliters
Body mass index(BMI) more than 30 kilogram/square meters
Appetite questionnaire score more than 20
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Absence of vitamin and mineral supplements use over the past 2 months
Absence of using any weight loss products or diet
Absence of the liver, kidney, thyroid, diabetes, AIDS and other metabolic diseases
Lack of using lipid lowering, blood-thinning and beta-blocker drugs
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Intervention groups
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The zinc group had received a capsule containing 30 mili gram zinc gluconate per day, while the control group had received a capsule contaning 30 miligram indigestible starch as placebo.
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Main outcome variables
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Leptin, ghrelin , C-Reactive Protein (CRP)