Determination of the effect of licorice extract on testosterone and Sex hormone binding globulin (SHBG), LH, FSH, Insulin, FBS, LDL, HDL, TG, Cholesterol, sleep quality, depression, and appetite in participants with polycystic ovary syndrome (PCOS) and overweight / obesity.

Determining the effect of licorice extract on sex hormone binding testosterone and globulin (SHBG) in patients with polycystic ovary syndrome (PCOS) with overweight or obesity

randomized double blind controlled clinical trial, parallel group

Of the obese women referring to the Imam Ali Clinic in Yazd, 72 people will be selected and randomly divided into two groups. The participants and investigator will not be aware of the drugs and placebo. The amount of sex hormones will be measured before and after of the intervention. Intervention is parallel and is performed in 8 weeks.

1) Age 18-45 years 2) BMI 25-35 3) Polycystic ovary syndrome according to Rotterdam criteria 1)Blood pressure equal or more than 90/140 mmHg 2)Cardiovascular diseases with regular medication 3)Liver, kidney and thyroid disorders, diabetes 4)Smoking 5)Taking multi vitamin-mineral supplements 6)Antioxidant and herbal treatments during the previous 3 months 7)Pregnancy and lactation 8)Consumption of licorice more than 300 gr per week 9)hereditary adrenal hyperplasia, Cushing's syndrome, hyperprolactinemia and thyroid dysfunction (hypothyroidism) or androgen-secreting tumors 10)history of allergy to licorice or any of its compounds 11)The study did not include patients taking estrogen or progesterone, but those who had previously been treated with metformin continued to receive it. Moreover, the patients were not included if they had taken new drugs within two month before and during the study.

Intervention: capsule containing 500 mg licorice extract three times daily Control: Placebo capsule containing Corn starch three times daily

Serum testosterone level; Serum SHBG level; Anthropometric measurements (height, weight, BMI, waist circumference, hip circumference, waist to hip ratio); Body composition.

Some essential data were omitted due to oversight during the initial registration, so this update has been made to complete them.

Randomization: Simple Random unit: Individual Tool: Randomized Tables A balanced block method is used to allocate concealment so that the number of samples assigned to each of the groups is equal.

Supplements of licorice and placebo in the same capsules in terms of size, color and shape Encodes A and B on supplements and placebo

There is no further information