Effect of Dorema Ammoniacum Cream on the prevention of peripheral intravenous catheter-related phlebitis In patients admitted to surgery departments

Determining the effect of Dorema Ammoniacum cream on the prevention of phlebitis caused by peripheral venous catheters in patients admitted to the surgical wards of Shariati Hospital

Clinical trial has two groups of intervention (Dorema Ammoniacum cream) and control (cream base). Assignment of samples to two groups with a random permutation block design will be two treatments with quadruple blocks. The study is three-way blind and the sample size is 55 people in each group.

This study is a three-blind randomized clinical trial in two groups. The patient, the researcher, the research assistant and the statistical analyzer have no knowledge of how the cans are named and the contents inside. After analyzing the data, the cream manufacturer will be asked about the contents of the cans. The research will be performed in the surgical ward of Shariati Hospital in Tehran. The study population was all patients admitted to the surgical ward and the research sample was all patients with peripheral venous catheter and at risk of phlebitis.

Inclusion criteria: Hospitalization in the surgical ward The patient is alert and able to understand and describe pain Necessary desire and cooperation from the patient The age of the samples is between 18 and 60 years Exclusion criteria: Grade 2, 3 and 4 phlebitis Fever

There are two intervention groups, the experimental group that receives the Dorema Ammoniacum cream and the control group that receives the cream base.

Degree of phlebitis

After adapting the patient's condition to the inclusion criteria, patients are randomly assigned to one of the two experimental or control groups. Thus, the letter A is considered for the intervention group and the letter B is considered for the control group. Then we write all the permutation combinations of the letters A, A, B and B, which are 6 different combinations, on 6 cards as follows: AABB, ABBA, ABAB, BAAB, BABA, BBAA, then we randomly select a digit from 1 to 6 (With the help of a table of random numbers or we ask patient number one to choose a card at random). For example, if the number 2 is selected, it means that the first person in the intervention group will be the next two people in the control group and the fourth person in the intervention group, and we will continue this operation until the sample size reaches the quorum.

The blinding of the study is that the Dorema Ammoniacum cream and placebo made by the research team are both completely similar in terms of color, odor, consistency and cans used, and the cans are named A and B by the cream maker. The patient, the researcher and the assistant researcher and the statistical analyzer have no information about how to name the cans and the contents inside them, and finally, after analyzing the data, the manufacturer of the cream will be asked about the contents of the cans.