The effect of Aoutologus Conditioned Serum on histological and radiographic characteristics of hard tissue after Horizontal Bone Augmentation and Socket Preservation surgery

The aim of this study was to improve the characteristics of bone tissue in the site of implant placement and to investigate the effect of Autologous Conditioned Serum on histological and radiographic characteristics of hard tissue after Horizontal Bone Augmentation or Socket preservation in Tabriz University of Medical Sciences.

This clinical trial has a control group, with parallel groups, single blinded, randomized, phase 3 on 21 patients. In this study, the control and intervention group will be one group and two areas of oral hard tissue will be considered as control and intervention.

Study place: Department of Periodontics, Dental Clinic, Tabriz University of Medical Sciences and Health Services

Inclusion criteria: The difficulty of surgery based on the dimensions required for agmentation, as well as the condition of the existing tooth before extraction and the condition of the ridge of one side compared to the other side should be the same, patients should require implant placement in the area and satisfied to surgery. Exclusion criteria: use of drugs that may interfere with the treatment process, the presence of systemic disease, smokers, inflammation or infection or pain during surgery, recent history of use of nonsteroidal anti-inflammatory drugs, patients with gastrointestinal problems, allergies to NSAIDs and pregnancy

intervention group Includes placement of an ACS-impregnated membrane in the postoperative area. Control Group includes placement of a membrane without ACS in the postoperative area.

Alkaline phosphatase activity, Tissue mineralization rate, Number of cells per unit area, Collagen content Gene expansion, Horizontal dimension of bone, Hansfield number

A random sampling method is available among people referring to the periodontics department of Tabriz Dental School. The method of randomization is simple and its unit is individual. Our tool is to randomize the table of random numbers. Also, treatment was assigned to patients randomly. The type of treatment was identified by code A (intervention) and B (control) and placed inside sealed envelopes; The envelopes were then placed in a bag and shaken. Then, it was accidentally taken out of the bag, and after observing the code, the treatment was given to the patient. None of the patients were informed about the treatment of another patient. The evaluator was not aware of the type of treatment.

Only the facilitator (supervisor) who is not involved in the collection and analysis of study data and the researcher who will place the material in two areas of the oral hard tissue will be aware of the study groupings and the researcher, the data analyzer And the test subject will be blinded. The study will be performed single blinded. In fact, the test subject will not be aware of the use of ACS in the surgical area.