Compare the efficacy of two methods of Double Ovarian Stimulation for enhancing oocyte yield in assisted reproductive technology in patients with poor ovarian response
The efficacy of Double Ovarian Stimulation for enhancing oocyte yield in assisted reproductive technology in patients with poor ovarian response
Design
En Intervention group: In group A, first a course of contraceptive pills was given to patients and then on the first to third day of mensturation ultrasound was done and cinnafact was administered at a dose of 50 units for three days and on the third day Pergoverisis administered twice daily and only Pergoveris continued. Ultrasound is performed on the fifth day of ovulation stimulation to examine the size of the grown follicles. When one or two follicles reach a size of 18 mm, triggering was done with decapeptyl 0/2 Mg administered simultaneously with 10,000 units HCGa way that three to five days after the initial ovulation, the patient was given two ampoules of Pergoveris again when the size of the follicle reached 18 mm. Triggering was done by decaptil 0/2 mg and HCG 10000 units.
Settings and conduct
Patients with low respons ovarian reserve (poseidn 3,4)
IVF and Infertility Center of Taleghani Hospital (Shahid Beheshti UNiversity).
Participants/Inclusion and exclusion criteria
Poor ovarian stimulation based on Poseidon group 3 criteria, AMH less than 1.2 ng / ml, antral follicle count less than 5 and age less than 35 years Group 4 poseidon includes older age equal to 35 years and AMH less than 1.2 ng/ml and the number of antral follicles less than 5 follicles.
People with normal or excessive ovarian response will not be included in the study.
Intervention groups
Poor ovarian stimulation based on Poseidon group 3 criteria, AMH less than 1.2 ng / ml, antral follicle count less than 5 and age less than 35 years Group 4 poseidon includes older age equal to 35 years and AMH less than 1.2 ng/ml and the number of antral follicles less than 5 follicles.
Main outcome variables
Number of oocytes, number of embryos, number of blastocysts.
General information
Reason for update
Acronym
Duostim
IRCT registration information
IRCT registration number:IRCT20200804048303N1
Registration date:2021-07-01, 1400/04/10
Registration timing:prospective
Last update:2021-07-01, 1400/04/10
Update count:0
Registration date
2021-07-01, 1400/04/10
Registrant information
Name
Samaneh Sheibani
Name of organization / entity
Country
Iran (Islamic Republic of)
Phone
+98 21 2223 9220
Email address
samane.sheibani@yahoo.com
Recruitment status
Recruitment complete
Funding source
Expected recruitment start date
2021-07-23, 1400/05/01
Expected recruitment end date
2021-09-21, 1400/06/30
Actual recruitment start date
empty
Actual recruitment end date
empty
Trial completion date
empty
Scientific title
Compare the efficacy of two methods of Double Ovarian Stimulation for enhancing oocyte yield in assisted reproductive technology in patients with poor ovarian response
Public title
The efficacy of Double Ovarian Stimulation for enhancing oocyte yield in assisted reproductive technology in patients with poor ovarian response
Purpose
Treatment
Inclusion/Exclusion criteria
Inclusion criteria:
Poor ovarian stimulation based on Poseidon group 3 criteria, AMH less than 1.2 ng / ml, antral follicle count less than 5 and age less than 35 years Group 4 poseidon includes older age equal to 35 years and AMH less than 1.2 ng/ml and the number of antral follicles less than 5 follicles
Group 4 poseidon includes older age equal to 35 years and AMH less than 1.2 ng/ml and the number of antral follicles less than 5 follicles
Exclusion criteria:
Women with normal or excessive ovarian response
Women with excessive ovarian response
Compare the number of oocytes and MII oocytes after induction ovulation in the follicular and luteal phase and two methods flare stimulation and minimal stimulation,
Method of measurement
Ultrasonography and puncture of oocytes and evaluate the presence of a polar body.
2
Description
Number of embryos.
Timepoint
Number of embryos after induction ovulation and oocyte retrieval in follicular and luteal phase and compare two methods of flare stimulation and minimal stimulation.
Method of measurement
Inspection of embryos under the microscope.
3
Description
Number of blastocysts.
Timepoint
The number of blastocysts after oocyte retrieval in the follicular and luteal phases and compare the two methods of flare stimulation and minimal stimulation.
Method of measurement
Inspection of embryos under the microscope 5days after oocyte retrieval.
Secondary outcomes
1
Description
Clinical pregnancy
Timepoint
4-6 weeks after embryo transfer(ET)
Method of measurement
Transvaginal ultrasonography and observe existence of gestational sac and fetal heart rate
Intervention groups
1
Description
Intervention group: In group A, first a course of contraceptive pills was given to patients and then on the first to third day of mensturation ultrasound was done and cinnafact was administered at a dose of 50 units for three days and on the third day Pergoverisis administered twice daily and only Pergoveris continued. Ultrasound is performed on the fifth day of ovulation stimulation to examine the size of the grown follicles. When one or two follicles reach a size of 18 mm, triggering was done with decapeptyl 0/2 Mg administered simultaneously with 10,000 units HCGa way that three to five days after the initial ovulation, the patient was given two ampoules of Pergoveris again when the size of the follicle reached 18 mm. Triggering was done by decaptil 0/2 mg and HCG 10000 units.
Category
Treatment - Drugs
2
Description
Intervention group: In group B, after a course of contraceptive pills, on the first to third day of mensturation ultrasound was done, then letrozol 2/5 mg twice a day orally for five days from third day of menstration was started for patients wih injection of one pergoveris per day in 6th and 7th cycle- days. Follicular size was fallowed with transvaginal sonography When leading follicle was reached to 18mm 10,000 units HCG + 0/2 mg decapeptile was given intramuscularly. Then compared the results of the study between the two groups, including the number of oocytes recovered, the number of blastocysts found in the biopsy, the number of embryos transferred and the number of cases of successful clinical fertility.In the luteal phase, the GnRH antagonist will be considered.In such a way that three to five days after the initial ovulation, the patient was given two ampoules of Pergoveris again when the size of the follicle reached 18 mm. Triggering was done by decaptil 0/2 mg and HCG 10000 units.Then compared the results of the study between the two groups, including the number of oocytes recovered, the number of blastocysts found in the biopsy, the number of embryos transferred and the number of cases of successful clinical fertility.