Comparison of the effect of misoprostol and letrozole in the first-trimester abortion of patients referring to Ganjavian Hospital in Dezful in 1400

A comparative study of the therapeutic effects of two different letrozole and misoprostol regimens in the first-trimester abortion

single-blind

Proper counseling will be done and written informed consent will be obtained before starting the treatment regimen. Group A patients will receive 2 misoprostol tablets orally and two vaginally in the posterior fornix of the vagina (800μg ) and this dose will be repeated up to 3 times every 4 hours as needed. In groups B and c, 10 mg of oral letrozole (2.5 mg) was administered twice daily for 3 and 5 days, respectively, on the last day of letrozole administration, patients will be hospitalized and receive vaginal misoprostol 400 μg of misoprostol vaginally , 400 μg of misoprostol will be used sublingually in both groups.

Inclusion criteria: hemoglobin level more than 10 gr/liter , diastolic pressure less than 95 mm Hg, gestational age less than 14 weeks Exclusion criteria: use of drugs in the last three months for abortion, pregnancy pruritis , adrenal disorders, porphyria, steroid-dependent cancer, acute or chronic liver disease ، thromboembolism, history of chronic lung diseases ، known allergy to letrozole or misoprostol, lactation, multifetal pregnancy, more than two previous cesarean sections, history of uterine surgery and myomectomy, contraindications to misoprostol and letrozole, intrauterine devices, uncontrolled seizures, coagulation disorder or use Anticoagulants, Active liver disease, Cardiovascular disease, Glucocorticoid use

In this interventional study, 75 pregnant women under 14 weeks of gestational age who are candidates for therapeutic abortion will be selected and divided into three groups using the block randomization method (n=25 in each group).

Medical abortion

In order to randomize the samples and also to balance the study groups, patients will be divided into 3 groups by the block randomization method by the researcher. In this method, the researcher will place each patient in one of 3 groups: A (misoprostol) or B (3-day letrozole + misoprostol) or C (5-day letrozole + misoprostol). Blocking in the form of six blocks One will be done and 8 blocks will be formed according to the number of sample population. We predict all possible arrangements of groups, for example, the first block will be AABBCC and the next block. For example, it will be predicted as CAB CAB and the rest of the blocks will be defined in the same way. Due to the large number of blocks, block randomization software will be used and then 8 blocks will be selected randomly with the help of a table of random numbers. Individuals will also be randomly selected and placed in blocks. Eventually, the sample size will be the same in the groups and 25 patients will be in each group A, B and C.

Participants in the study will be placed in three ABC groups by the researcher. Patient randomization will be done by the researcher in blocks and after coding, the study and control groups will enter the data for analysis in the software The group treated with misoprostol with code A, the group treated with letrozole 3 days + misoprostol with code B and the group treated with letrozole 5 days + misoprostol with code C will be coded. It should be noted that the participants in the study do not know about the treatment and medication regimen performed for them, but researchers and statistical analysts know what diet each participant received.

All documents and statistical tests and the results will be mentioned in the form of graphs and tables in the final article

Access period starts 6 months after the results are published

By publishing the article, all people who have access to the Internet can access the results

In order to develop the science related to abortion treatment and facilitate the process with the least complications, everyone will be able to access

It will be available on Google Scholar by mentioning the names of the authors and keywords

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