Comparison of the effect of morphine and oxycodone in relieving pain in patients with bone metastasis pain

The effect of morphine with oxycodone in relieving pain in patients is compared with pain due to bone metastases

Randomized clinical trial, with parallel groups, double-blind, phase 3 on 32 patients, block method and online software www.sealedenvelope.com were used for randomization.

This study is a double-blind randomized clinical trial in Khansari Hospital in Arak in 1399 with easy sampling. All patients who are candidates for analgesia and have inclusion criteria will be evaluated as the study population after completing the informed consent form. In this study, 32 patients are divided into two completely equal groups using morphine and oxycodone using block randomization. Due to the two-sided blindness of the study, in this study, only specialists The person in charge of the study is aware of the type of study and the study groups, while patients are not aware of the type of prescription drug. It is not aware and only recognizes groups based on A and B and fills checklists accordingly.

Inclusion criteria: Patients with malignancy with bone metastasis confirmed by bone scan Candidate for analgesia, vas less than 6. Exclusion criteria: history of diabetes and kidney failure, bone fracture, hypotension, bradypnea

In the first intervention group, 16 patients received 5 mg morphine intravenously and placebo tablets only once at the beginning of the intervention and in the second intervention group, 16 patients took two 5 mg oxycodone tablets orally, together and by injection alone. Once received at the beginning of the intervention.

Pain

Using block randomization method and online statistical software (www.sealedenvelope.com), 32 patients will be divided into two equal groups of intervention and control in 8 blocks of 4. To hide random sequences, the sealed envelope method is used. First, a random sequence is created by one of the mentioned methods. , Are prepared and each of the random sequences created is recorded on a card and the cards are placed in the envelopes in order. In order to maintain a random sequence, the envelopes are numbered in the same way on the outer surface. Finally, the lids of the envelopes are glued and placed inside a box, respectively. At the beginning of the registration of participants, according to the order of entry of eligible participants into the study, one of the envelopes is opened in order and the assigned group of the participant is revealed.

Due to the double-blindness of the study, blindness is such that only the relevant specialist in charge is aware of the type of the study and groups , while patients are not aware of the type of prescription drug and blind using injectable and oral placebo. Also, the clinical caregivers and interns in charge of the project, who are in charge of filling out the checklists, are not aware of the type of groups based on the prescription drug and only recognize the groups based on A and B and check the checklists.