To evaluate the effect of single dose prophylactic vancomycin before semi-permanent catheterization to prevent catheter related infection: Randomized Controlled Trial, Phase 2

Determining the rate of reduction of infection with vancomycin before semi-permanent catheterization in 1399 in Golestan Hospital

The study was performed as a randomized double-blind clinical trial based on a random number table. Patients with chronic renal failure admitted to the nephrology ward of Ahvaz Golestan Hospital who need dialysis and hemodialysis dual catheter installation are examined.

The study was conducted as a randomized double-blind clinical trial based on a random number table. Patients with chronic renal failure admitted to the nephrology ward of Ahvaz Golestan Hospital who require dialysis and installation of a double-sided hemodialysis catheter are examined. The intervention group receives one gram of vancomycin antibiotic by intravenous injection one hour before catheterization. The control group receives normal saline in the same volume by a person who is not aware of the research. The patient and the people evaluating the final outcomes have no knowledge of grouping the people into the intervention and control groups.

- Patient with ESRD - Not using antibiotics before the study - Sterile conditions during catheter installation - Lack of evidence of infection in other parts of the body - Satisfaction to participate in the study

To evaluate the effect of vancomycin antibiotic before semi-permanent catheterization to prevent catheter-dependent infection, the intervention group received one gram of vancomycin antibiotic by intravenous injection and normal saline with the same volume one hour before catheterization.

The main outcome variables in this study included reviewing and comparing the incidence of catheter related infection over a period of 6 months; The time of the catheter related infection.

Individuals are randomly divided into two groups based on the method of 4 random block permutations. The site sealedenvelope.com Randomization section under Creat a List section was used to generate a randomization sequence.

In this study, physicians, nurses, data collectors, those assessing the consequences, and the Safety and Data Monitoring Committee were kept blind. In order to eliminate the bias caused by the knowledge of them, the results are based on the type of treatment received and its possible impact on the research result of the study in a double-blind manner. Similar vials were used for vancomycin and placebo, and randomization was performed by sealedenvelope.com, according to which each patient was placed in the treatment or control group.