Survey the effect of oral erythromycin(low dose) on feeding tolerance in admitted premature neonates at imam Reza hospital NICU

The purpose of this study was to evaluate the effectiveness of oral erythromycin(low dose) on feeding tolerance in admitted premature neonates at kermanshah-imam Reza hospital NICU.The inclusion criteria were : preterm babies with gestational age between 28-34 w and birth weight between 1000-1800gr 2)postnatal age less than 3 days of life Exclusion criteria were: 1) birth asphexia 2) electrolyte imbalance3) the presence of major congenital abnormalities; 4) necrotizing enterocolitis 5)formula feeding 6)cyanotic congenital heart disease 7)usage of prokinetic agents ( such as metoclopramide) 8)mechanical ventilation 9) history of surgery . preterm newborns with postnatal age less than 3 days were included. The sample size included 70 preterm neonates.newborns were randomized (using parallel blocks of 10 according to apredetermined list of random number) to receive one of the following 2groups: case group(n=35) received oral erythromycin(2.5 mg/kg/q6h for ten 10 days) and control group( no intervention)(n=35) .The neonate in both groups received breast milk. And feeding started within the first three days of life. The primary outcome measure was the duration required by the infant to achieve full enteral feeds(150ml/kg/day for at least 24h .The Secondary outcome measures were duration of hospital admission and vomiting.

Kermanshah University of Medical Sciences‎